Barbouti Alexandra, Varvarousis Dimitrios N, Kanavaros Panagiotis
Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Antioxidants (Basel). 2025 Apr 28;14(5):529. doi: 10.3390/antiox14050529.
Preeclampsia is a hypertension condition of human pregnancy that poses a significant risk to pregnant women and their fetus. It complicates about 2-8% of human pregnancies worldwide and displays multifactorial pathogenesis, including increased placental oxidative stress because of disturbed utero-placental blood flow. Recent evidence suggests that increased oxidative stress promotes acceleration of the placental senescence which is implicated in the pathogenesis of preeclampsia. This review focuses on the mechanisms that lead to oxidative stress in preeclamptic patients and examines the role of oxidative stress-induced placental senescence in the pathogenesis of the disease.
子痫前期是人类孕期出现的一种高血压病症，对孕妇及其胎儿构成重大风险。全球约2 - 8%的人类妊娠会出现子痫前期并发症，其发病机制具有多因素性，包括因子宫 - 胎盘血流紊乱导致胎盘氧化应激增加。最近的证据表明，氧化应激增加会促使胎盘衰老加速，而这与子痫前期的发病机制有关。本综述着重探讨子痫前期患者发生氧化应激的机制，并研究氧化应激诱导的胎盘衰老在该疾病发病机制中的作用。
