Yordanov Angel, Tsoneva Eva
Department of Gynaecological Oncology, Medical University Pleven, 5800 Pleven, Bulgaria.
Department of Reproductive Medicine, Specialized Hospital for Active Treatment of Obstetrics and Gynaecology Dr Shterev, 1330 Sofia, Bulgaria.
Antioxidants (Basel). 2025 Apr 30;14(5):540. doi: 10.3390/antiox14050540.
Reactive oxygen species modulator 1 (ROMO1) is a nuclear-encoded inner mitochondrial protein known for its dual role as a modulator of reactive oxygen species (ROS) and a non-selective ion channel. Initially identified for its role in ROS production, ROMO1 has garnered attention for its functional properties as a non-selective ion channel that regulates ion homeostasis in mitochondria. This article examines ROMO1 from both perspectives, emphasizing its structural and functional characteristics, physiological roles, and implications in health and disease. Understanding ROMO1's dual functionality provides insight into its potential as a therapeutic target for oxidative stress-related disorders, especially cancer progression.
活性氧调节剂1（ROMO1）是一种核编码的线粒体内蛋白，因其作为活性氧（ROS）调节剂和非选择性离子通道的双重作用而闻名。ROMO1最初因其在ROS产生中的作用而被发现，后来因其作为调节线粒体离子稳态的非选择性离子通道的功能特性而受到关注。本文从这两个角度对ROMO1进行了研究，重点阐述了其结构和功能特征、生理作用以及在健康和疾病中的意义。了解ROMO1的双重功能有助于深入了解其作为氧化应激相关疾病（尤其是癌症进展）治疗靶点的潜力。
