Majdalawieh Amin F, Khatib Bayan K, Terro Tala M
Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Advanced Biosciences and Bioengineering Research Center, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Biomolecules. 2025 May 7;15(5):681. doi: 10.3390/biom15050681.
α-Mangostin, a bioactive xanthone derived from the L. Clusiaceae () fruit, has demonstrated significant anti-inflammatory and immunomodulatory properties. Chronic inflammation plays a critical role in the pathogenesis of various diseases, including metabolic disorders, autoimmune conditions, and cancer. Conventional anti-inflammatory therapies, such as non-steroidal anti-inflammatory drugs (NSAIDs), often carry undesirable side effects, prompting the need for safer, natural alternatives. This review consolidates the existing literature on the mechanisms by which α-mangostin exerts its anti-inflammatory effects, including the suppression of pro-inflammatory cytokines, modulation of immune cell activity, and inhibition of key signaling pathways such as nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). Additionally, α-mangostin exhibits immunomodulatory properties by influencing both innate and adaptive immune responses, affecting macrophage polarization, T cell differentiation, and cytokine production. Its efficacy has been observed in numerous disease models, including joint disorders, digestive and metabolic conditions, hepatic diseases, neurological disorders, and respiratory ailments. The potential therapeutic applications of α-mangostin as an anti-inflammatory agent warrant further investigation through preclinical and clinical studies to validate its efficacy and safety.
α-山竹黄酮是一种从藤黄科水果中提取的具有生物活性的氧杂蒽酮，已显示出显著的抗炎和免疫调节特性。慢性炎症在包括代谢紊乱、自身免疫性疾病和癌症在内的各种疾病的发病机制中起着关键作用。传统的抗炎疗法，如非甾体抗炎药（NSAIDs），往往会带来不良副作用，因此需要更安全的天然替代品。这篇综述整合了关于α-山竹黄酮发挥抗炎作用机制的现有文献，包括抑制促炎细胞因子、调节免疫细胞活性以及抑制关键信号通路，如核因子-κB（NF-κB）和丝裂原活化蛋白激酶（MAPK）。此外，α-山竹黄酮通过影响先天和适应性免疫反应、影响巨噬细胞极化、T细胞分化和细胞因子产生，展现出免疫调节特性。在众多疾病模型中，包括关节疾病、消化和代谢疾病、肝脏疾病、神经疾病和呼吸系统疾病，均观察到了其疗效。α-山竹黄酮作为一种抗炎剂的潜在治疗应用值得通过临床前和临床研究进行进一步调查，以验证其疗效和安全性。
