Palumbo Carla, Paganelli Francesca, Ferretti Marzia
Department of Biomedical, Metabolic and Neural Sciences, Section of Human Morphology, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40136 Bologna, Italy.
Biomolecules. 2025 May 16;15(5):733. doi: 10.3390/biom15050733.
This Commentary is intended to start a discussion in the field of calcification/ossification related to osteogenesis. It highlights that two types of bone formation, static osteogenesis (SO) and dynamic osteogenesis (DO), are temporally followed by each other in bone histogenesis and bone lesion repair. Moreover, they also represent the common denominator in the pathological processes of both calcification and peculiar ossifications, such as heterotopic ossification and the formation of supernumerary skeletal segments. The final objective is to propose a different interpretation of certain bone alterations/pathologies, attributable to the two peculiar osteogenesis patterns (SO and DO), occurring in both physiological and pathological conditions. From these reflections, new approaches in the definition of diagnosis and therapies of certain alterations could be derived.
本述评旨在引发钙化/骨化领域中与骨生成相关的讨论。它强调在骨组织发生和骨病变修复过程中，静态骨生成（SO）和动态骨生成（DO）这两种骨形成类型在时间上相继出现。此外，它们也是钙化和特殊骨化（如异位骨化和多余骨骼节段形成）病理过程的共同特征。最终目的是对某些生理和病理条件下出现的、归因于两种特殊骨生成模式（SO和DO）的骨改变/病理提出不同的解释。通过这些思考，可以得出某些改变的诊断和治疗定义方面的新方法。
