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电子烟或雾化产品使用相关肺损伤:综述

E-Cigarette or Vaping Product Use-Associated Lung Injury: A Comprehensive Review.

作者信息

Amjad Mohammad Asim, Ocazionez Trujillo Daniel, Estrada-Y-Martin Rosa M, Cherian Sujith V

机构信息

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine, University of Texas Health-McGovern Medical School, 6431 Fannin Street, MSB 1.434, Houston, TX 77030, USA.

Department of Diagnostic and Interventional Imaging, University of Texas Health-McGovern Medical School, Houston, TX 77030, USA.

出版信息

Int J Environ Res Public Health. 2025 May 17;22(5):792. doi: 10.3390/ijerph22050792.

DOI:10.3390/ijerph22050792
PMID:40427906
Abstract

E-cigarette or vaping product use-associated lung injury (EVALI) is a critical and potentially fatal form of lung injury that gained considerable public health concern in 2019. The use of e-cigarettes and vaping products is causally associated with EVALI, a condition characterized by a constellation of respiratory symptoms, such as coughing, shortness of breath, and chest pain. This comprehensive narrative literature review explores the complexities of EVALI, including its association with the structure and composition of e-cigarettes and its epidemiology, pathogenesis, clinical and radiological manifestations, management strategies, and public health implications. Moreover, it uncovers the long-term repercussions of EVALI and underscores the ongoing research endeavors designed to mitigate and comprehend the risks associated with using e-cigarettes.

摘要

电子烟或雾化产品使用相关肺损伤(EVALI)是一种严重且可能致命的肺损伤形式,在2019年引起了相当大的公共卫生关注。电子烟和雾化产品的使用与EVALI存在因果关系,EVALI是一种以一系列呼吸道症状为特征的疾病,如咳嗽、呼吸急促和胸痛。这篇全面的叙述性文献综述探讨了EVALI的复杂性,包括其与电子烟的结构和成分的关联及其流行病学、发病机制、临床和放射学表现、管理策略以及公共卫生影响。此外,它还揭示了EVALI的长期影响,并强调了为减轻和理解与使用电子烟相关的风险而正在进行的研究工作。

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本文引用的文献

1
E-cigarette, or Vaping, Product Use Associated Lung Injury: Epidemiology, Challenges, and Implications With COVID-19.电子烟或雾化产品使用相关肺损伤:流行病学、挑战及与2019冠状病毒病的关联
Pediatr Pulmonol. 2025 Jan;60(1):e27448. doi: 10.1002/ppul.27448. Epub 2024 Dec 23.
2
The Evolution of a Pediatric Public Health Crisis: E-cigarette or Vaping-Associated Lung Injury.儿科公共卫生危机的演变:电子烟或雾化相关肺损伤
Pediatrics. 2024 May 1;153(5). doi: 10.1542/peds.2023-063484.
3
Review of quantitative and functional lung imaging evidence of vaping-related lung injury.
电子烟相关肺损伤的定量和功能性肺部成像证据综述。
Front Med (Lausanne). 2024 Jan 24;11:1285361. doi: 10.3389/fmed.2024.1285361. eCollection 2024.
4
Molecular Imaging of Pulmonary Inflammation in Users of Electronic and Combustible Cigarettes: A Pilot Study.电子香烟和可燃香烟使用者肺部炎症的分子成像:一项初步研究。
J Nucl Med. 2023 May;64(5):797-802. doi: 10.2967/jnumed.122.264529. Epub 2023 Jan 19.
5
Pulmonary surfactant function and molecular architecture is disrupted in the presence of vaping additives.在存在电子烟添加剂的情况下,肺表面活性物质的功能和分子结构会受到破坏。
Colloids Surf B Biointerfaces. 2023 Feb;222:113132. doi: 10.1016/j.colsurfb.2023.113132. Epub 2023 Jan 6.
6
The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report.电子烟或蒸气产品使用相关肺损伤流行:发病机制、管理和未来方向:美国胸科学会官方研讨会报告。
Ann Am Thorac Soc. 2023 Jan;20(1):1-17. doi: 10.1513/AnnalsATS.202209-796ST.
7
Vegetable glycerin e-cigarette aerosols cause airway inflammation and ion channel dysfunction.蔬菜甘油电子烟烟雾会导致气道炎症和离子通道功能障碍。
Front Pharmacol. 2022 Sep 26;13:1012723. doi: 10.3389/fphar.2022.1012723. eCollection 2022.
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Propylene glycol, a component of electronic cigarette liquid, damages epithelial cells in human small airways.丙二醇,电子烟液的一种成分,会损害人体小气道的上皮细胞。
Respir Res. 2022 Aug 23;23(1):216. doi: 10.1186/s12931-022-02142-2.
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