Evran Turan, Özçınar Hüseyin, Çopur İsmet, Bilgili Beliz
Department of Anesthesiology and Reanimation, Faculty of Medicine, Pamukkale University, 20070 Denizli, Turkey.
Department of Computer Education and Instructional Technology, Faculty of Education, Pamukkale University, 20070 Denizli, Turkey.
Healthcare (Basel). 2025 May 14;13(10):1146. doi: 10.3390/healthcare13101146.
(1) Background: The aim of this bibliometric study is to analyze global research trends, citation impact, and scientific collaborations in the field of neuromuscular blockers (NMBAs) and their antagonists between 2000 and 2024. (2) Methods: Data were retrieved from the Web of Science Core Collection (WoSCC) using Boolean search strategies. Bibliometric analyses were conducted using R bibliometrix, VOSviewer, and CiteSpace software to visualize collaboration networks, keyword trends, and citation bursts. (3) Results: A total of 499 articles were analyzed, with the United States of America (USA), China, and South Korea leading in productivity, while France had the highest citation impact. Influential authors included Mertes PM and Fuchs-Buder T. Emerging topics such as sugammadex, sevoflurane, and neuromuscular monitoring were identified, reflecting a shift from pharmacokinetic studies to safety and monitoring strategies. (4) Conclusions: The findings indicate a marked increase in studies on neuromuscular monitoring and reversal agents, such as sugammadex, over the past two decades. The USA, France, and China emerged as the most contributory countries in NMBAs research, with their extensive international collaborations playing a pivotal role in shaping scientific progress. Highly influential studies have predominantly focused on NMBA pharmacokinetics, safety, anaphylaxis risks, and the clinical benefits of sugammadex, underscoring its critical role in reducing residual neuromuscular blockade (rNMB) and enhancing patient safety.
(1) 背景：本文献计量学研究旨在分析2000年至2024年期间神经肌肉阻滞剂（NMBAs）及其拮抗剂领域的全球研究趋势、引文影响力和科学合作情况。(2) 方法：使用布尔搜索策略从科学网核心合集（WoSCC）检索数据。使用R bibliometrix、VOSviewer和CiteSpace软件进行文献计量分析，以可视化合作网络、关键词趋势和引文爆发情况。(3) 结果：共分析了499篇文章，美国、中国和韩国在产出方面领先，而法国的引文影响力最高。有影响力的作者包括Mertes PM和Fuchs-Buder T。确定了诸如舒更葡糖钠、七氟烷和神经肌肉监测等新兴主题，反映了从药代动力学研究向安全和监测策略的转变。(4) 结论：研究结果表明，在过去二十年中，神经肌肉监测和逆转剂（如舒更葡糖钠）的研究显著增加。美国、法国和中国成为NMBAs研究中贡献最大的国家，它们广泛的国际合作在塑造科学进步方面发挥了关键作用。极具影响力的研究主要集中在NMBA的药代动力学、安全性、过敏风险以及舒更葡糖钠的临床益处，突出了其在减少残余神经肌肉阻滞（rNMB）和提高患者安全性方面的关键作用。
