全球 MERS-CoV 研究趋势：2012 年至 2021 年的综合文献计量分析。

BACKGROUND: The Middle East respiratory syndrome coronavirus (MERS-CoV) was first reported in Saudi Arabia in 2012. So far, the cases of MERS-CoV have been reported in 27 countries. The virus causes severe health complications, resulting high mortality. AIM: The current study aimed to evaluate the global research trends and key bibliometric indices in MERS-CoV research from 2012 to 2021. METHODS: A retrospective bibliometric and visualized study was conducted. The Science Citation Index Expanded Edition of Web of Science Core Collection database was utilized to retrieve published scientific literature on MERS-CoV. The retrieved publications were assessed for a number of bibliometric attributes. The data were imported into HistCite and VOSviewer software to calculate the citations count and perform the visualization mapping, respectively. In addition, countries or regions collaboration, keywords analysis, and trend topics in MERS-CoV were assessed using the Bibliometrix: An R-tool. RESULTS: A total of 1,587 publications, published in 499 journals, authored by 6,506 authors from 88 countries or regions were included in the final analysis. Majority of these publications were published as research article ( = 1,143). Globally, these publications received 70,143 citations. The most frequent year of publication was 2016 ( = 253), while the most cited year was 2014 (11,517 citations). The most prolific author was Memish ZA ( = 94), while the most published journal was Emerging Infectious Diseases ( = 80). The United States of America (USA) ( = 520) and Saudi Arabia ( = 432) were the most influential and largest contributors to the MERS-CoV publications. The extensively studied research area was infectious diseases. The most frequently used author keywords other than search keywords were Saudi Arabia, SARS-CoV-2, COVID-19, epidemiology, transmission, spike protein, vaccine, outbreak, camel, and pneumonia. CONCLUSION: This study provides an insight into MERS-CoV-related research for scientific community (researchers, academicians) to understand and expand the basic knowledge structure, potential collaborations, and research trend topics. This study can also be useful for policy makers. After the emergence of MERS-CoV, a significant increase in scientific production was observed in the next 4 years (2013-2016). In 2021, the trend topics in MERS-CoV-related research were COVID-19, clinical characteristics, and cytokine storm. Saudi Arabia had the strongest collaboration with the USA, while the USA had the highest collaboration with China.

背景：中东呼吸综合征冠状病毒（MERS-CoV）于 2012 年在沙特阿拉伯首次报告。迄今为止，已有 27 个国家报告了 MERS-CoV 病例。该病毒导致严重的健康并发症，死亡率很高。

目的：本研究旨在评估 2012 年至 2021 年 MERS-CoV 研究的全球研究趋势和关键文献计量学指标。

方法：采用回顾性文献计量和可视化研究。利用 Web of Science 核心合集数据库的科学引文索引扩展版检索 MERS-CoV 的已发表科学文献。评估检索出版物的多项文献计量属性。将数据导入 HistCite 和 VOSviewer 软件，分别计算引文计数并进行可视化映射。此外，使用 Bibliometrix：一个 R 工具评估 MERS-CoV 中的国家或地区合作、关键词分析和趋势主题。

结果：最终分析共纳入 1587 篇发表于 499 种期刊、来自 88 个国家或地区的 6506 位作者的出版物。这些出版物中，大多数为研究文章（=1143 篇）。全球范围内，这些出版物共获得 70143 次引用。发文量最多的年份是 2016 年（=253 篇），而被引频次最多的年份是 2014 年（11517 次）。最有影响力的作者是 Memish ZA（=94 篇），发文量最多的期刊是《新发传染病》（=80 篇）。美国（=520 篇）和沙特阿拉伯（=432 篇）是 MERS-CoV 出版物的最具影响力和最大贡献者。传染病是研究最广泛的领域。除了检索关键词外，使用最频繁的作者关键词是沙特阿拉伯、SARS-CoV-2、COVID-19、流行病学、传播、刺突蛋白、疫苗、暴发、骆驼和肺炎。

结论：本研究为科学界（研究人员、学者）提供了对 MERS-CoV 相关研究的深入了解，以帮助他们理解和扩展基础知识结构、潜在合作以及研究趋势主题。本研究也可以为决策者提供参考。MERS-CoV 出现后，在接下来的 4 年（2013-2016 年），科学产出显著增加。2021 年，MERS-CoV 相关研究的趋势主题是 COVID-19、临床特征和细胞因子风暴。沙特阿拉伯与美国的合作最为密切，而美国与中国的合作最为密切。