一种用于表征不同潮气量下肺组织体内介电特性的改进Cole-Cole模型：一项动物研究。
An Improved Cole-Cole Model for Characterizing In Vivo Dielectric Properties of Lung Tissue at Different Tide Volumes: An Animal Study.
作者信息
Qin Yangchun, Zhang Liang, Han Tixin, Liu Yifan, Liu Xuechao, Fu Feng, Wang Hang, Qu Shuoyao, Zhao Zhanqi, Yang Lin, Dai Meng
机构信息
Department of Military Biomedical Engineering, The Fourth Military Medical University, Xi'an 710032, China.
Basic Medical Science Academy, The Fourth Military Medical University, Xi'an 710032, China.
出版信息
Bioengineering (Basel). 2025 Apr 24;12(5):445. doi: 10.3390/bioengineering12050445.
OBJECTIVE
The air content within the lungs directly influences the dielectric properties of lung tissue; however, previous studies were conducted under ex vivo conditions and without quantitatively controlling air volume. This study aims to develop an improved model using in vivo measurements to accurately characterize the dielectric properties of rabbit lung tissue across various tidal volumes.
METHODS
In this study, six sets of different tidal volumes (30, 40, 50, 60, 70, 80 mL) were set in the frequency band of 100 MHz~1 GHz to analyze the trend of the dielectric properties, and the dielectric parameters were systematically constructed under the conditions of different tidal volumes.
RESULTS
It was found that the conductivity and permittivity of rabbit lung tissue showed a decreasing trend with increasing tidal volume in the measuring frequency band. The traditional Cole-Cole model has limitations in simulating the dielectric properties of in vivo lung tissues. Therefore, by refining and optimizing the model, this study successfully reduced the average error between the measured data and the model fitting to less than 5%.
CONCLUSIONS
This study lays the groundwork for investigating the relationship between total air volume within the lungs and their dielectric properties in vivo.
目的
肺内的空气含量直接影响肺组织的介电特性；然而，以往的研究是在离体条件下进行的，且未对空气量进行定量控制。本研究旨在开发一种改进的模型，利用体内测量来准确表征不同潮气量下兔肺组织的介电特性。
方法
本研究在100 MHz~1 GHz频段设置了六组不同的潮气量（30、40、50、60、70、80 mL），以分析介电特性的变化趋势，并在不同潮气量条件下系统构建介电参数。
结果
发现在测量频段内，兔肺组织的电导率和电容率随潮气量增加呈下降趋势。传统的Cole-Cole模型在模拟体内肺组织的介电特性方面存在局限性。因此，通过对模型进行细化和优化，本研究成功地将测量数据与模型拟合之间的平均误差降低到5%以下。
结论
本研究为研究肺内总空气量与其体内介电特性之间的关系奠定了基础。
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