Beshara Amani, Yitzhak Avraham, Guterman Revital, Elhayany Ruhama, Khader Majd, Weissmann Sarah, Abu-Freha Naim
Hillel Yaffe Medical Center, Hadera 3820302, Israel.
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel.
Diagnostics (Basel). 2025 May 11;15(10):1209. doi: 10.3390/diagnostics15101209.
Constipation is one of the most common gastrointestinal complaints among women, with a variety of contributing factors. We aimed to assess the role of colonoscopy in evaluating young women with constipation. A multi-center, large cohort, retrospective study included all data from colonoscopies performed between 2016 and 2023 in seven endoscopy departments. The indications and findings of the procedures were collected, and findings of young women aged ≤40 y with constipation as an indication were compared to older women and men of the same age groups. The cohort comprised 377,795 patients, including 198,629 (52.6%) females and 179,166 (47.4%) males. In total, 7872 females underwent colonoscopy for constipation and other indications . In addition, 6852 women were referred for a colonoscopy for constipation only . In sum, 75% of colonoscopies in women <40 y were normal in both cohorts. In inflammatory bowel diseases (IBD) were significantly higher in women <40 y with Ulcerative Colitis (UC) (1.2%) and Crohn's disease (CD) (0.7%), < 0.001). The rate of IBD was lower but still significant in . In both cohorts, diverticulosis and polyp rates exponentially increased with age >40 y, < 0.001. Higher rates of diverticulosis and polyps were found among males <40 y in One case (0.1%) of Colorectal cancer (CRC) was found in <40 y women. Similar IBD and CRC rates were found in males and females of all ages, > 0.05. The diagnostic yield of colonoscopy for investigating isolated constipation in young females is not significant. Diagnostic work-up should be guided by accurate clinical understanding.
便秘是女性中最常见的胃肠道疾病之一，有多种促成因素。我们旨在评估结肠镜检查在评估患有便秘的年轻女性中的作用。一项多中心、大型队列回顾性研究纳入了2016年至2023年期间在七个内镜科室进行的所有结肠镜检查数据。收集了这些检查的指征和结果，并将以便秘为指征的40岁及以下年轻女性的检查结果与同年龄组的老年女性和男性进行了比较。该队列包括377795名患者，其中女性198629名（52.6%），男性179166名（47.4%）。共有7872名女性因便秘和其他指征接受了结肠镜检查。此外，有6852名女性仅因便秘被转诊进行结肠镜检查。总体而言，在两个队列中，40岁以下女性的结肠镜检查有75%结果正常。40岁以下患有溃疡性结肠炎（UC）（1.2%）和克罗恩病（CD）（0.7%）的女性中炎症性肠病（IBD）的发生率显著更高（P<0.001）。IBD的发生率在……中较低但仍具有显著性。在两个队列中，憩室病和息肉发生率均随年龄>40岁呈指数增长（P<0.001）。在……中，40岁以下男性的憩室病和息肉发生率更高。在40岁以下女性中发现1例（0.1%）结直肠癌（CRC）。在所有年龄段的男性和女性中发现了相似的IBD和CRC发生率（P>0.05）。结肠镜检查对年轻女性单纯性便秘的诊断率不显著。诊断检查应以准确的临床认识为指导。
