Murat Sema, Kamburoğlu Kıvanç, Vazquez Diego, Nart Leonardo Jorge, Azcona Victoria, Benitez Lorena Elizabeth, Awawdeh Mohammed, Aboelmaaty Wael
Department of Prosthodontics, Faculty of Dentistry, Ankara University, Ankara 06560, Turkey.
Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara University, Ankara 06560, Turkey.
Diagnostics (Basel). 2025 May 14;15(10):1247. doi: 10.3390/diagnostics15101247.
This study aimed to evaluate the accuracy of CBCT-based volumetric measurements of maxillary defects and to investigate the effects of different CBCT devices, kVp settings, and segmentation software on measurement accuracy. CBCT images from eight patients with maxillary defects were used to generate 3D-printed models for volumetric assessment. Two CBCT systems (Largev Smart and Planmeca Promax) were evaluated at three different kVp settings. Volume calculations were conducted using ITK-SNAP version 4.2.2 and 3D Doctor version 4.0 software, while micro-CT served as the gold standard (GS) for comparison. Statistical analysis included a three-way ANOVA to assess the effect of CBCT parameters and software on volumetric accuracy. Additionally, post-hoc Tukey HSD analysis was performed to identify specific differences between kVp groups, and Pearson correlation analysis was used to evaluate consistency with the GS. Significance level was set at < 0.05. Higher kVp settings significantly improved volumetric accuracy, with 100 kVp yielding the smallest deviations (-3.77%) from the GS. Tukey HSD analysis revealed significant differences between 60-80 kVp ( = 0.008), 60-100 kVp ( < 0.001), and 80-100 kVp ( = 0.041), confirming the influence of kVp on accuracy. No significant differences were observed between CBCT devices or software programs ( > 0.05). A strong positive correlation (r = 0.96) between CBCT-derived and micro-CT volumes confirmed CBCT's reliability for volumetric assessments ( < 0.001). CBCT provides accurate volumetric measurements of maxillary defects, particularly at higher kVp settings. These findings support its clinical application for preoperative planning and postoperative evaluation, offering a cost-effective alternative to micro-CT.
本研究旨在评估基于CBCT的上颌骨缺损容积测量的准确性，并研究不同CBCT设备、千伏峰值（kVp）设置和分割软件对测量准确性的影响。使用8例上颌骨缺损患者的CBCT图像生成用于容积评估的3D打印模型。在三种不同的kVp设置下对两种CBCT系统（Largev Smart和Planmeca Promax）进行了评估。使用ITK-SNAP 4.2.2版本和3D Doctor 4.0版本软件进行容积计算，而微型CT作为比较的金标准（GS）。统计分析包括三因素方差分析，以评估CBCT参数和软件对容积准确性的影响。此外，进行了事后Tukey HSD分析以确定kVp组之间的具体差异，并使用Pearson相关分析来评估与金标准的一致性。显著性水平设定为<0.05。较高的kVp设置显著提高了容积准确性，100 kVp与金标准的偏差最小（-3.77%）。Tukey HSD分析显示60 - 80 kVp（=0.008）、60 - 100 kVp（<0.001）和80 - 100 kVp（=0.041）之间存在显著差异，证实了kVp对准确性的影响。在CBCT设备或软件程序之间未观察到显著差异（>0.05）。CBCT得出的容积与微型CT容积之间存在强正相关（r = 0.96），证实了CBCT在容积评估方面的可靠性（<0.001）。CBCT能够对上颌骨缺损进行准确的容积测量，尤其是在较高的kVp设置下。这些发现支持其在术前规划和术后评估中的临床应用，为微型CT提供了一种经济有效的替代方案。
