文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

基于聚类的退行性颈椎疾病探索性影像学表型分析:一项回顾性研究。

Exploratory Cluster-Based Radiographic Phenotyping of Degenerative Cervical Disorder: A Retrospective Study.

作者信息

Lew Si-Hyung, Jeong Ye-Jin, Roh Ye-Ri, Kang Dong-Ho

机构信息

College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

ALLIV Healthcare Co., Seoul 05070, Republic of Korea.

出版信息

Medicina (Kaunas). 2025 May 19;61(5):916. doi: 10.3390/medicina61050916.


DOI:10.3390/medicina61050916
PMID:40428875
Abstract

: Degenerative cervical myelopathy (DCM), a major subtype of degenerative cervical disorders, presents with diverse sagittal alignment patterns. However, radiography-based phenotyping remains underexplored. This study aimed to identify distinct cervical alignment subgroups using unsupervised clustering analysis and to explore their potential clinical relevance. : We analyzed 1371 lateral cervical radiographs of patients with DCM. C3-C7 sagittal vertical axis (SVA), lordosis, vertical length, and curved length were determined. K-means clustering was applied, and the optimal cluster number was determined using the elbow method and silhouette analysis. Clustering validity was assessed using the Calinski-Harabasz and Davies-Bouldin indices. : The final clustering solution was validated with a high Calinski-Harabasz index (1171.70) and an acceptable Davies-Bouldin index (0.99) at k = 3, confirming the stability and robustness of the classification. Cluster 1 (forward-head type) exhibited low lordosis (8.3° ± 4.7°), moderate SVA (95.9 ± 60.2 mm), and a compact cervical structure, consistent with kyphotic alignment and forward-head displacement. Cluster 2 (normal) showed the highest lordosis (24.1° ± 6.8°), moderate SVA (70.6 ± 50.2 mm), and balanced sagittal alignment, indicating a biomechanically stable cervical posture. Cluster 3 (long-neck type) displayed the highest SVA (135.6 ± 76.7 mm), the longest vertical and curved lengths, and moderate lordosis, suggesting a structurally elongated cervical spine with anterior head displacement. Significant differences ( < 0.01) were observed across all clusters, confirming distinct phenotypic patterns in cervical sagittal alignment. : This exploratory clustering analysis identified three distinct radiographic phenotypes of DCM, reflecting biomechanical heterogeneity. Although prospective studies linking these phenotypes to clinical outcomes are warranted, our findings provide a framework for personalized spinal care in the future.

摘要

退行性颈椎脊髓病(DCM)是退行性颈椎疾病的一种主要亚型,呈现出多样的矢状位排列模式。然而,基于X线摄影的表型分析仍未得到充分探索。本研究旨在通过无监督聚类分析确定不同的颈椎排列亚组,并探讨它们潜在的临床相关性。

我们分析了1371例DCM患者的颈椎侧位X线片。测定了C3 - C7矢状垂直轴(SVA)、前凸、垂直长度和曲度长度。应用K均值聚类法,并使用肘部法和轮廓分析确定最佳聚类数。使用Calinski - Harabasz指数和Davies - Bouldin指数评估聚类有效性。

最终聚类结果在k = 3时,通过高Calinski - Harabasz指数(1171.70)和可接受的Davies - Bouldin指数(0.99)得到验证,证实了分类的稳定性和稳健性。第1组(头部前倾型)前凸较低(8.3°±4.7°),SVA适中(95.9±60.2 mm),颈椎结构紧凑,与后凸排列和头部前倾移位一致。第2组(正常型)前凸最高(24.1°±6.8°),SVA适中(70.6±50.2 mm),矢状位排列平衡,表明颈椎姿势在生物力学上稳定。第3组(长颈型)SVA最高(135.6±76.7 mm),垂直和曲度长度最长,前凸适中,提示颈椎结构拉长且头部向前移位。在所有聚类组间均观察到显著差异(<0.01),证实了颈椎矢状位排列存在不同的表型模式。

这项探索性聚类分析确定了DCM的三种不同的影像学表型,反映了生物力学异质性。尽管有必要进行前瞻性研究将这些表型与临床结果联系起来,但我们的发现为未来的个性化脊柱护理提供了一个框架。

相似文献

[1]
Exploratory Cluster-Based Radiographic Phenotyping of Degenerative Cervical Disorder: A Retrospective Study.

Medicina (Kaunas). 2025-5-19

[2]
Anterior cervical discectomy and fusion can restore cervical sagittal alignment in degenerative cervical disease.

Eur J Orthop Surg Traumatol. 2019-5

[3]
Cervical sagittal alignment in adult hyperkyphosis treated by posterior instrumentation and in situ bending.

Orthop Traumatol Surg Res. 2017-2

[4]
Clinical Impact of T1 Slope Minus Cervical Lordosis After Multilevel Posterior Cervical Fusion Surgery: A Minimum 2-Year Follow Up Data.

Spine (Phila Pa 1976). 2017-12-15

[5]
Impact of global spine balance and cervical regional alignment on determination of postoperative cervical alignment after laminoplasty.

Medicine (Baltimore). 2018-11

[6]
Postural Consequences of Cervical Sagittal Imbalance: A Novel Laboratory Model.

Spine (Phila Pa 1976). 2015-6-1

[7]
The impact of standing regional cervical sagittal alignment on outcomes in posterior cervical fusion surgery.

Neurosurgery. 2012-9

[8]
Does Preoperative T1 Slope and Cervical Lordosis Mismatching Affect Surgical Outcomes After Laminoplasty in Patients with Cervical Spondylotic Myelopathy?

World Neurosurg. 2019-7-4

[9]
Global Spinal Alignment in Patients With Cervical Spondylotic Myelopathy.

Spine (Phila Pa 1976). 2018-2-1

[10]
A retrospective study to reveal the effect of surgical correction of cervical kyphosis on thoraco-lumbo-pelvic sagittal alignment.

Eur Spine J. 2016-7

本文引用的文献

[1]
Fourteen-Year Retrospective Cohort Study on the Impact of Climatic Factors on Chronic Musculoskeletal Pain: A Spanish Primary Care Analysis.

Int J Rheum Dis. 2025-3

[2]
Cervical spondylotic myelopathy and radiculopathy: a stepwise approach and comparative analysis of surgical outcomes: a narrative review of recent literature.

Asian Spine J. 2025-2

[3]
K-Line Tilt May Influence the Short-Term Surgical Outcomes After Laminoplasty in Patients With Degenerative Cervical Myelopathy.

Global Spine J. 2025-5

[4]
Machine learning-based cluster analysis identifies four unique phenotypes of patients with degenerative cervical myelopathy with distinct clinical profiles and long-term functional and neurological outcomes.

EBioMedicine. 2024-8

[5]
Differences in musculoskeletal dysfunctions and in postural alterations between chronic migraine and chronic tension type headache: A cross-sectional study.

J Bodyw Mov Ther. 2024-1

[6]
An Algorithmic Roadmap for the Surgical Management of Degenerative Cervical Myelopathy: A Narrative Review.

Asian Spine J. 2024-4

[7]
Smartphone addiction and postural alterations in the cervical region in adolescents.

Rev Paul Pediatr. 2023

[8]
Are disease-specific patient-reported outcomes measures (PROMs) used in cardiogenetics? A systematic review.

Eur J Hum Genet. 2024-6

[9]
Risk Factors for Postoperative Loss of Lordosis, Cervical Kyphosis, and Sagittal Imbalance After Cervical Laminoplasty.

World Neurosurg. 2023-12

[10]
Impact of the K-line in patients with ossification of the posterior longitudinal ligament: Analysis of sagittal cervical curvature changes and surgical outcomes.

Front Surg. 2023-2-15

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索