Kaya Ahmet, Karahan Mahmut Alp, Bingol Tanriverdi Tugba, Esercan Alev, Bostanci Erkmen Melike, Tanriverdi Zulkif
Department of Anesthesiology and Reanimation, Mehmet Akif Inan Training and Research Hospital, University of Health Science, Sanliurfa 63040, Turkey.
Department of Obstetrics and Gynecology, Kanuni Training and Research Hospital, University of Health Science, Trabzon 61250, Turkey.
Medicina (Kaunas). 2025 May 19;61(5):919. doi: 10.3390/medicina61050919.
: Post-term pregnancies are associated with increased risks of perinatal complications. This study aimed to evaluate potential cardiac electrophysiological changes in pregnant women by comparing the QRS duration, interval of corrected QT (QTc), and frontal QRS-T angle [f(QRS-T)] between term and post-term pregnancies. : In this observational prospective study, 120 pregnant women were enrolled-60 term (37-41 weeks) and 60 post-term (≥42 weeks). All participants underwent standard 12-lead electrocardiography (ECG) and caesarean section with spinal anaesthesia. The QTc interval, QRS duration, and frontal QRS-T angle were measured. Demographic parameters such as age, gestational week, height, and weight were recorded. The SPSS software was used to analyse the data with < 0.05 as the threshold for significance. : Post-operative QTc interval (417.3 ± 20.5 vs. 410.2 ± 14.5, = 0.032) and f(QRS-T) (28 [16-55] vs. 22 [14-34], = 0.042) were significantly higher in the post-term group than in the term group. When the change in the f(QRS-T) angle was analysed, there was a significant widening of this angle in the post-term group (from 21 [11-37] to 28 [16-55], = 0.002). The increased f(QRS-T) angle reflects greater heterogeneity in ventricular depolarisation and repolarisation, which may indicate sub-clinical myocardial stress or altered autonomic regulation in the post-term period. Although no overt arrhythmias were observed, subtle changes in P-wave morphology and QT dispersion were more prevalent in the post-term group. : Prolonged QRS duration and an increased f(QRS-T) angle in post-term pregnancies can reflect the underlying changes in cardiac electrophysiology related to prolonged gestation. These ECG parameters may serve as non-invasive indicators of sub-clinical cardiac stress, which could be relevant for anaesthetic risk assessment and perinatal management.
过期妊娠与围产期并发症风险增加相关。本研究旨在通过比较足月妊娠和过期妊娠孕妇的QRS波时限、校正QT间期(QTc)和额面QRS-T角[f(QRS-T)],评估孕妇潜在的心脏电生理变化。
在这项观察性前瞻性研究中,纳入了120名孕妇,其中60名足月妊娠(37 - 41周),60名过期妊娠(≥42周)。所有参与者均接受标准12导联心电图(ECG)检查,并在脊髓麻醉下进行剖宫产。测量QTc间期、QRS波时限和额面QRS-T角。记录年龄、孕周、身高和体重等人口统计学参数。使用SPSS软件分析数据,以P < 0.05作为显著性阈值。
过期妊娠组术后QTc间期(417.3 ± 20.5 vs. 410.2 ± 14.5,P = 0.032)和f(QRS-T)(28 [16 - 55] vs. 22 [14 - 34],P = 0.042)显著高于足月妊娠组。分析f(QRS-T)角的变化时,过期妊娠组该角度显著增宽(从21 [11 - 37]增至28 [16 - 55],P = 0.002)。f(QRS-T)角增大反映心室去极化和复极化的异质性增加,这可能表明过期妊娠后期存在亚临床心肌应激或自主神经调节改变。虽然未观察到明显心律失常,但过期妊娠组P波形态和QT离散度的细微变化更为普遍。
过期妊娠时QRS波时限延长和f(QRS-T)角增大可反映与孕周延长相关的心脏电生理潜在变化。这些心电图参数可作为亚临床心脏应激的非侵入性指标,这可能与麻醉风险评估和围产期管理相关。