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2型糖尿病患者血压管理的支柱:近期试验的见解与新观点

Pillars of Blood Pressure Management in Patients with Type 2 Diabetes Mellitus: Insights from Recent Trials and Emerging Perspectives.

作者信息

Pop Călin, Petriş Antoniu Octavian, Pop Lavinia, David Liliana Elisabeta

机构信息

County Emergency Hospital Baia Mare, 2nd Department Faculty of Nursing and Health Sciences, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400337 Cluj Napoca, Romania.

Cardiology Clinic, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaşi, Romania.

出版信息

J Clin Med. 2025 May 8;14(10):3269. doi: 10.3390/jcm14103269.

DOI:10.3390/jcm14103269
PMID:40429265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12112238/
Abstract

Hypertension (HTN) is prevalent among patients with type 2 diabetes mellitus (T2DM), and both conditions are well-established risk factors for cardiovascular diseases (CVDs) and microvascular complications. To mitigate the risk of CVD, a comprehensive management approach for both blood pressure (BP) and glycaemic control is essential. The current therapeutic strategy should be structured around five pillars aimed at confirming HTN, establishing the 10-year CVD risk and its components and focusing on pharmacological treatment alongside lifestyle interventions to achieve BP targets. In clinical practice, the recommended BP target is 120-129/70-79 mmHg, while an optimal target of ≤120/70 mmHg is being explored under research conditions. Further, BP control should be re-evaluated in cases of resistant or uncontrolled HTN, in conjunction with antidiabetic therapies that have demonstrated cardiovascular and renal protective benefits. This five-pillar approach offers a comprehensive and evolving perspective on BP management in patients with T2DM, although certain aspects continue to be refined as new evidence emerges.

摘要

高血压(HTN)在2型糖尿病(T2DM)患者中很常见,这两种情况都是公认的心血管疾病(CVD)和微血管并发症的危险因素。为降低CVD风险,对血压(BP)和血糖控制采取综合管理方法至关重要。当前的治疗策略应围绕五个支柱构建,旨在确诊HTN、确定10年CVD风险及其组成部分,并侧重于药物治疗以及生活方式干预以实现血压目标。在临床实践中,推荐的血压目标是120 - 129/70 - 79 mmHg,而在研究条件下正在探索≤120/70 mmHg的最佳目标。此外,对于难治性或未控制的HTN病例,应结合已证明具有心血管和肾脏保护益处的抗糖尿病疗法重新评估血压控制情况。这种五支柱方法为T2DM患者的血压管理提供了一个全面且不断发展的视角,尽管随着新证据的出现,某些方面仍在不断完善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c559/12112238/2c550f198416/jcm-14-03269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c559/12112238/2c550f198416/jcm-14-03269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c559/12112238/2c550f198416/jcm-14-03269-g001.jpg

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Intensive Blood-Pressure Control in Patients with Type 2 Diabetes.2型糖尿病患者的强化血压控制
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Associations of blood pressure with cardiovascular and mortality outcomes in over 2 million older persons with or without diabetes mellitus: A systematic review and meta-analysis of 45 cohort studies.200多万患有或未患有糖尿病的老年人中血压与心血管及死亡结局的关联:45项队列研究的系统评价和荟萃分析
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