Abdul-Razzak Jaqueline, Ionescu Mihaela, Diaconu Radu, Popescu Alexandru Dan, Niculescu Elena Carmen, Petrescu Ileana Octavia, Singer Cristina Elena, Coșoveanu Carmen Simona, Anghelina Liliana, Gheonea Cristian
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Pediatrics "Mother and Child", Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
J Clin Med. 2025 May 8;14(10):3289. doi: 10.3390/jcm14103289.
: Asthma outcomes in children and adolescents largely depend on parental adherence to prescribed treatment plans. This study investigates how the COVID-19 pandemic influenced parental decision-making in managing their children's asthma, regardless of whether the children were infected with SARS-CoV-2. : In this research, 146 children with asthma were analyzed based on the following data: demographic parameters (gender, age group, and residence), before and after measurements of FeNO and pulmonary function test parameters were performed to assess the evolution of asthma for infected and non-infected children, exacerbations, parents' compliance with the treatment, changes in treatment steps performed by physicians, and the GINA asthma control levels. : The effect of parent self-management of doses was evident in the variation of FeNO and pulmonary function test parameters before and after COVID-19 disease, including children with asthma who did not contract the virus, in the decrease in well-controlled asthma cases, as well as in the number of exacerbations per year. A step-down in treatment doses was statistically associated with increased FeNO values ( < 0.0005), and decreased FEV1 values ( = 0.025). Higher values of FeNO were statistically significantly associated with a higher number of exacerbations per year ( < 0.0005). There was a statistically significant moderately strong association between the treatment steps evolution (decided by the attending physician) and parents' self-management of doses in the attempt to assess the control of the disease of children with asthma ( = 0.019). Also, 80.95% of children for whom the parents performed a step-down in dose no longer presented well-controlled asthma, leading to a statistically significant association relative to the level of asthma control and doses adjustments ( < 0.0005). : During epidemiological circumstances, a strong collaboration between the parents/caregivers/pediatric patients with asthma and attending physicians is essential to correctly assess the symptoms and to comply the asthma treatment with ICS and a bronchodilator in order to control the disease.
儿童和青少年的哮喘治疗效果在很大程度上取决于家长对规定治疗方案的依从性。本研究调查了新冠疫情如何影响家长对其子女哮喘的管理决策，无论子女是否感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。：在本研究中，基于以下数据对146名哮喘儿童进行了分析：人口统计学参数（性别、年龄组和居住地），对感染和未感染儿童进行呼出气一氧化氮（FeNO）测量以及肺功能测试参数测量前后的数据，以评估哮喘的演变情况、病情加重情况、家长对治疗的依从性、医生所采取治疗步骤的变化以及全球哮喘防治创议（GINA）哮喘控制水平。：家长自我管理剂量的效果在新冠疾病前后FeNO和肺功能测试参数的变化中很明显，包括未感染病毒的哮喘儿童、哮喘控制良好病例数的减少以及每年病情加重的次数。治疗剂量的降低与FeNO值升高（<0.0005）以及第一秒用力呼气容积（FEV1）值降低（=0.025）在统计学上相关。较高的FeNO值与每年较高的病情加重次数在统计学上显著相关（<0.0005）。在试图评估哮喘儿童疾病控制情况时，治疗步骤的演变（由主治医生决定）与家长自我管理剂量之间存在统计学上显著的中度强关联（=0.019）。此外，80.95%的家长降低剂量的儿童不再表现为哮喘控制良好，这导致哮喘控制水平与剂量调整之间存在统计学上显著的关联（<0.0005）。：在疫情期间，哮喘患儿的家长/照顾者/患儿与主治医生之间的密切合作对于正确评估症状以及遵守吸入性糖皮质激素（ICS）和支气管扩张剂的哮喘治疗方案以控制疾病至关重要。
