Lee Chia-Yi, Yang Shun-Fa, Huang Jing-Yang, Lian Ie-Bin, Chang Chao-Kai
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Nobel Eye Institute, Taipei 10041, Taiwan.
J Clin Med. 2025 May 15;14(10):3458. doi: 10.3390/jcm14103458.
: The aim of this study was to evaluate the effectiveness of using low-dose atropine (ATR) at different instillation frequencies on myopia control in a low-myopia population. : A retrospective cohort study was conducted, and patients using 0.01% ATR and exhibiting a myopia degree ranging from +0.00 to -1.00 diopter (D) were included. A total of 32 and 26 eyes from 32 and 26 individuals were included in the daily group and two-day group, respectively. The main outcomes of this study are the progression of the spherical equivalent refraction (SER) and the elongation of the axial length (AXL). The Mann-Whitney U test and generalized linear model were used to perform the statistical analysis. : After a follow-up period of one year, the change in SER was similar between the daily group and two-day group (-0.24 ± 0.09 versus -0.26 ± 0.08, = 0.393). In addition, there was an insignificant difference in AXL elongation between the daily group and two-day group (0.09 ± 0.07 versus 0.10 ± 0.09, = 0.655). The trends observed in SER progression ( = 0.604) and AXL elongation ( = 0.779) were statistically identical between the daily group and the two-day group. : The results of the two-day use of low-dose ATR regarding SER and AXL control are similar to those with the daily use of low-dose ATR in children with low myopia.
本研究的目的是评估在低近视人群中，不同滴注频率使用低剂量阿托品（ATR）对控制近视的有效性。进行了一项回顾性队列研究，纳入使用0.01% ATR且近视度数在+0.00至-1.00屈光度（D）之间的患者。每日组和两日组分别纳入了32名个体的32只眼和26只眼。本研究的主要结果是等效球镜度（SER）的进展和眼轴长度（AXL）的延长。采用曼-惠特尼U检验和广义线性模型进行统计分析。随访一年后，每日组和两日组的SER变化相似（-0.24±0.09对-0.26±0.08，P = 0.393）。此外，每日组和两日组在AXL延长方面无显著差异（0.09±0.07对0.10±0.09，P = 0.655）。每日组和两日组在SER进展（P = 0.604）和AXL延长（P = 0.779）方面观察到的数据趋势在统计学上是相同的。低剂量ATR两日使用在控制SER和AXL方面的结果与低近视儿童每日使用低剂量ATR的结果相似。
