Watt Natalie Ann, Hockley Nicholas, Armitage James Andrew
School of Medicine (Optometry), Faculty of Health, Deakin University, 75 Pigdons Road, Geelong 3216, Australia.
J Clin Med. 2025 May 16;14(10):3501. doi: 10.3390/jcm14103501.
Peripheral retinal degenerations (PRDs) are structural anomalies in the outer regions of the retina, typically emerging in adolescence and early adulthood. Early detection is crucial, as some PRDs can lead to sight-threatening complications, such as retinal detachment, if left unmanaged. Due to a paucity of research regarding PRDs and their association with axial length (AL) and refractive error (RE) in young Australian adults, this study aimed to investigate the prevalence of PRDs in this population and establish whether AL and RE could help predict the likelihood of PRD occurrence. : A cross-sectional study was conducted on a mixed population ( = 221) of Australian adults aged 18 to 40. Demographic data, RE, AL, and a series of ultra-widefield (UWF) retinal images were obtained from participants' undilated eyes using the Zeiss Clarus 500. : The overall PRD prevalence was 8.15% ( = 442 eyes). Binary logistic regression revealed that a longer AL was a more significant factor in increasing the risk of PRD development across all myopia classifications compared to emmetropia than RE. The likelihood of a PRD was 50% at an AL of 26.9 mm and -6.50D of myopia, and 95% at 29.6 mm and -11.00D. : PRD prevalence was lower than reported in other global studies, perhaps reflecting the diverse ethnic makeup of the cohort. While our study supports the conventional understanding that longer ALs, and high myopia are key risk factors for developing a PRD, it also provides new insights into the likelihood of detecting a PRD at a given AL or RE in a mixed population. This information is crucial for eye care practitioners, enabling early identification of at-risk individuals and screening for PRDs that may increase the risk of retinal detachment.
周边视网膜变性（PRDs）是视网膜外层的结构异常，通常在青春期和成年早期出现。早期检测至关重要，因为如果不加以处理，一些PRDs可能会导致威胁视力的并发症，如视网膜脱离。由于关于澳大利亚年轻成年人中PRDs及其与眼轴长度（AL）和屈光不正（RE）之间关联的研究较少，本研究旨在调查该人群中PRDs的患病率，并确定AL和RE是否有助于预测PRD发生的可能性。：对221名年龄在18至40岁的澳大利亚成年混合人群进行了横断面研究。使用蔡司Clarus 500从参与者未散瞳的眼睛中获取人口统计学数据、RE、AL以及一系列超广角（UWF）视网膜图像。：PRD的总体患病率为8.15%（442只眼）。二元逻辑回归显示，与正视眼相比，在所有近视分类中，较长的AL是增加PRD发生风险的更重要因素，比RE更显著。当眼轴长度为26.9毫米且近视度数为-6.50D时，发生PRD的可能性为50%，当眼轴长度为29.6毫米且近视度数为-11.00D时，可能性为95%。：PRD患病率低于其他全球研究报告的水平，这可能反映了该队列的种族构成多样。虽然我们的研究支持传统观点，即较长的眼轴长度和高度近视是发生PRD的关键风险因素，但它也为在混合人群中在给定的眼轴长度或屈光不正情况下检测到PRD的可能性提供了新的见解。这些信息对眼科护理从业者至关重要，有助于早期识别高危个体并筛查可能增加视网膜脱离风险的PRDs。
