Tianjin Eye Hospital and Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, Tianjin, China.
Shanghai Guanghua Integrated Traditional Chinese and Western Medicine Hospital, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200052, China.
Cont Lens Anterior Eye. 2022 Apr;45(2):101470. doi: 10.1016/j.clae.2021.101470. Epub 2021 May 22.
To investigate the relationship between axial length (AL) and refractive error (RE).
Participants comprised Chinese university students. In total, 894 eyes with low hyperopia to emmetropia (-0.50D ≤ spherical equivalent (SE) ≤ +2.00D), and 1007 eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed. Cycloplegic RE and AL were measured with an autorefractor and IOL Master respectively. The association between AL and RE was evaluated by linear regression. Furthermore, differences in the mean AL, as well as the correlation between AL and ocular refraction, were evaluated according to SE, sex, and age.
In both the moderate to high myopia and low hyperopia to emmetropia groups, mean AL was significantly longer in men (26.48 mm, confidence interval (CI) 26.41-26.56 mm; 23.82 mm, CI: 23.76-23.88 mm, respectively) than in women (25.78 mm, CI: 25.71-25.86 mm; 23.25 mm, CI: 23.17-23.33 mm, respectively). For both men and women, mean AL significantly differed among four SE groups (+0.50D < SE ≤ +2.00D, -0.50D ≤ SE ≤ +0.50D, -4.00D ≤ SE ≤ -6.00D, SE < -6.00D, P < 0.001). The correlation coefficient between AL and ocular refraction was -0.318 and -0.277 in male and female participants, respectively, with low hyperopia to emmetropia (-0.50D ≤ SE ≤ +2.00D), and -0.545 and -0.437 in male and female participants, respectively, with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D). There were no age-related effects on SE (P = 0.714) or AL (P = 0.952).
Ocular refraction is negatively correlated with AL in Chinese university students. The correlation coefficient is greater in those with moderate to high myopia than in those with low hyperopia to emmetropia. Furthermore, the AL is longer in men than in women.
探讨眼轴长度（AL）与屈光不正（RE）的关系。
参与者为中国大学生。共分析了 894 只低度远视至正视眼（等效球镜度 -0.50D≤SE≤+2.00D）和 1007 只中高度近视眼（SE≤-11.00D）。采用自动屈光仪和 IOL Master 分别测量睫状肌麻痹后的 RE 和 AL。通过线性回归评估 AL 和 RE 之间的关系。此外，还根据 SE、性别和年龄评估了平均 AL 的差异以及 AL 与眼屈光的相关性。
在中高度近视组和低度远视至正视组中，男性的平均 AL 均明显长于女性（26.48mm，置信区间（CI）26.41-26.56mm；23.82mm，CI：23.76-23.88mm）（25.78mm，CI：25.71-25.86mm；23.25mm，CI：23.17-23.33mm）。对于男性和女性，四个 SE 组之间的平均 AL 差异均有统计学意义（+0.50D<SE≤+2.00D，-0.50D≤SE≤+0.50D，-4.00D≤SE≤-6.00D，SE<-6.00D，P<0.001）。在低度远视至正视眼（-0.50D≤SE≤+2.00D）中，男性和女性参与者的 AL 与眼屈光的相关系数分别为-0.318 和-0.277，在中高度近视眼（-11.00D≤SE≤-4.00D）中，男性和女性参与者的相关系数分别为-0.545 和-0.437。SE（P=0.714）或 AL（P=0.952）与年龄无相关性。
在中国大学生中，眼屈光与 AL 呈负相关。中高度近视的相关系数大于低度远视至正视眼。此外，男性的 AL 长于女性。
