Elec Florin Ioan, Moisoiu Tudor, Negrut Matei Florin, Simon Robert, Elec Alina Daciana, Muntean Adriana Milena, Horciag Georgeta, Sitaru Ana Maria, Rachisan Andreea Liana, Oniscu Gabriel, Antal Oana
Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, Romania.
Department of Urology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
J Clin Med. 2025 May 18;14(10):3540. doi: 10.3390/jcm14103540.
The Kidney Donor Profile Index (KDPI) is an important metric for evaluating the quality of donor kidneys and predicting post-transplant outcomes. The Estimated Post-Transplant Survival (EPTS) score is a tool for estimating kidney transplant candidates' long-term survival. However, their validity in Eastern European cohorts is yet to be explored. This study aimed to evaluate the predictive accuracy of the KDPI and EPTS in a local cohort. We conducted a seven-year retrospective observational study at a high-volume transplant center in Romania. Data from 353 patients who received kidney transplants from brain-dead donors (DBDs) between 2017 and 2023 were analyzed. The KDPI scores were stratified into <35%, 35-85%, and >85%, while EPTS was stratified into <20%, 20-60%, and >60%. Primary outcomes included one-, three-, and five-year post-transplant graft function as estimated by eGFR, while secondary outcomes involved patient and graft survival rates at one, three, and five years. Graft function and survival rates were significantly lower with increasing KDPI and EPTS scores, reinforcing the utility of both scores in clinical decision-making. Despite their limitations, KDPI and EPTS remain valuable predictors in our patient population.
肾脏供体特征指数（KDPI）是评估供体肾脏质量和预测移植后结果的重要指标。估计移植后生存率（EPTS）评分是一种用于估计肾移植受者长期生存率的工具。然而，它们在东欧人群中的有效性尚待探索。本研究旨在评估KDPI和EPTS在当地人群中的预测准确性。我们在罗马尼亚一家大型移植中心进行了一项为期七年的回顾性观察研究。分析了2017年至2023年间353例接受脑死亡供体（DBD）肾脏移植患者的数据。KDPI评分分为<35%、35 - 85%和>85%，而EPTS分为<20%、20 - 60%和>60%。主要结局包括移植后1年、3年和5年通过估算肾小球滤过率（eGFR）评估的移植肾功能，次要结局包括1年、3年和5年的患者和移植肾生存率。随着KDPI和EPTS评分的增加，移植肾功能和生存率显著降低，这进一步证明了这两个评分在临床决策中的实用性。尽管存在局限性，但KDPI和EPTS在我们的患者群体中仍然是有价值的预测指标。
