Bershteĭn L M, Aleksandrov V A
Eksp Onkol. 1985;7(4):29-32.
The N-nitrosomethylurea (NMU)-induced transplacental blastomogenesis in rats was studied under the effect of pre- and postnatal glucose administration. On the 21st day of pregnancy NMU (20 mg/kg) was intraperitoneally administered to rats. From the 7th day of pregnancy experimental rats were treated with 10% glucose solution instead of drinking water, and during 1.5 months after delivery they and their progeny were given 5% glucose solution. The foetal weight in glucose-treated pregnant rate increased. A significant increase of tumour frequency was detected in the progeny of these rats. In male progeny tumours of the nervous system and kidneys typical of NMU effect prevailed and in females--tumours of other organs and tissues, particularly of the mammary gland, pituitary and hemopoietic system. Possible mechanisms of the modifying effect of glucose on the transplacental blastomogenic action of NMU are discussed.
在产前和产后给予葡萄糖的影响下，研究了N-亚硝基甲基脲（NMU）诱导的大鼠经胎盘成瘤作用。在妊娠第21天，给大鼠腹腔注射NMU（20mg/kg）。从妊娠第7天起，用10%葡萄糖溶液代替饮用水对实验大鼠进行处理，在分娩后的1.5个月内，给它们及其后代给予5%葡萄糖溶液。葡萄糖处理的妊娠大鼠的胎儿体重增加。在这些大鼠的后代中检测到肿瘤发生率显著增加。在雄性后代中，以NMU作用典型的神经系统和肾脏肿瘤为主，在雌性后代中，则以其他器官和组织的肿瘤为主，特别是乳腺、垂体和造血系统的肿瘤。讨论了葡萄糖对NMU经胎盘成瘤作用的修饰作用的可能机制。
