Dimant I N, Beniashvili D Sh
Biull Eksp Biol Med. 1978 Mar;85(3):343-6.
Transplacental blastomogenic action of different carcinogenic agents (ethylnitrosourea--ENU), methylnitrosourea--MNU, dimethylbenzanthracene--DMBA, and benz(a)pyrene--BP) was studied in rabbits. As revealed, ENU had the greatest blastomogenic activity and an expressed neurotropic action. Relative tropism to different tissues characteristic of some carcinogenic agents during their action on adult organism was not always expressed in transplacental blastomogenesis, Study of the influence of different modifying factors (organospecific immunization, chronic irritation of the peripheral nerve, injection of the MNU) on the realization of transplacental blastomogenesis showed that their postnatal use stimulated mostly the appearance of the peripheral nerve timours in the offspring rabbits (MNU inhibited the development of tumours).
在兔子身上研究了不同致癌剂（乙基亚硝基脲——ENU、甲基亚硝基脲——MNU、二甲基苯并蒽——DMBA和苯并[a]芘——BP）的经胎盘致瘤作用。结果显示，ENU具有最强的致瘤活性和明显的亲神经作用。某些致癌剂作用于成年机体时对不同组织的相对嗜性在经胎盘致瘤过程中并不总是表现出来。研究不同修饰因素（器官特异性免疫、外周神经慢性刺激、注射MNU）对经胎盘致瘤作用实现的影响表明，它们在出生后使用主要刺激后代兔子外周神经肿瘤的出现（MNU抑制肿瘤发展）。
