Leucine-rich repeat receptor-like kinases (LRR-RLKs) are involved in the regulation of various biological processes, including plant growth, development, and responses to biotic and abiotic stresses. Foxtail millet (), an important cereal crop, has been extensively studied for its stress tolerance mechanisms. In this study, we performed a comprehensive phylogenetic analysis and chromosomal mapping of LRR-RLK genes in . A total of 285 genes were identified and classified into 12 subfamilies based on phylogenetic relationships. Chromosome localization analysis revealed that genes are unevenly distributed across the chromosomes, with certain regions showing gene clusters. Functional analysis of these genes under biotic and abiotic stress conditions suggested that several family members are involved in key stress response pathways. Expression profiling indicated differential expression patterns of genes in response to various stresses, including drought, salinity, and pathogen infection, highlighting their potential roles in stress adaptation. In conclusion, the phylogenetic and functional analysis of the gene family in provides valuable insights into their roles in stress responses and lays the groundwork for future studies aimed at enhancing stress tolerance in foxtail millet.