Wang Jiaqi, Man Kwan, Ng Kevin Tak-Pan
Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Int J Mol Sci. 2025 May 13;26(10):4662. doi: 10.3390/ijms26104662.
C-C motif ligand 11 (CCL11) is a multifunctional chemokine that regulates immunity, angiogenesis, and tissue remodeling. In addition to its allergic inflammation role, CCL11 exhibits context-dependent dual functions in relation to cancer progression. In liver diseases, it mediates injury, fibrosis, and inflammation while serving as a disease biomarker. This review systematically examines CCL11-receptor interactions and their immunomodulatory mechanisms in cancers and hepatic pathologies. We highlight CCL11's therapeutic potential as both a prognostic marker and immunotherapeutic target. By integrating molecular and clinical insights, this work advances the understanding of CCL11's pathophysiological roles and facilitates targeted therapy development.
C-C基序配体11（CCL11）是一种多功能趋化因子，可调节免疫、血管生成和组织重塑。除了在过敏性炎症中发挥作用外，CCL11在癌症进展方面还表现出依赖于环境的双重功能。在肝脏疾病中，它介导损伤、纤维化和炎症，同时作为一种疾病生物标志物。本综述系统地研究了CCL11与受体的相互作用及其在癌症和肝脏疾病中的免疫调节机制。我们强调了CCL11作为预后标志物和免疫治疗靶点的治疗潜力。通过整合分子和临床见解，这项工作加深了对CCL11病理生理作用的理解，并促进了靶向治疗的发展。
