Higashi K, Morita M, Tajiri J, Sato T, Okazaki K, Arai S
Endocrinol Jpn. 1985 Jun;32(3):421-6. doi: 10.1507/endocrj1954.32.421.
In order to obtain a good separation line between patients with primary hyperparathyroidism (1 degree HPT) and those with non-parathyroidal hypercalcemia (NPHC), serum chloride (Cl) and phosphate (P) concentrations were analyzed. Ninety-nine per cent of the patients with 1 degree HPT had a Cl/P ratio greater than or equal to 33, but 29% of patients with NPHC were also included in this range. When the (Cl-90)/P ratio was used to separate into two groups, 98% of the patients with 1 degree HPT had a ratio greater than or equal to 5.0, and 94% of the patients with NPHC had a ratio less than 5.0. From these results, while high sensitivity was achieved both with the Cl/P and (Cl-90)/P ratios, the (Cl-90)/P ratio provided higher specificity. Therefore we conclude that the (Cl-90)/P ratio was excellent in distinguishing 1 degree HPT from other types of hypercalcemia.
为了在原发性甲状旁腺功能亢进症（1度HPT）患者与非甲状旁腺性高钙血症（NPHC）患者之间获得良好的区分界限，对血清氯（Cl）和磷酸盐（P）浓度进行了分析。99%的1度HPT患者的Cl/P比值大于或等于33，但29%的NPHC患者也在此范围内。当使用（Cl-90）/P比值将患者分为两组时，98%的1度HPT患者的比值大于或等于5.0，94%的NPHC患者的比值小于5.0。从这些结果来看，虽然Cl/P比值和（Cl-90）/P比值都具有较高的敏感性，但（Cl-90）/P比值具有更高的特异性。因此，我们得出结论，（Cl-90）/P比值在区分1度HPT与其他类型的高钙血症方面表现出色。
