Tepavčević Vesna, Farkaš Agatić Zita, Pilipović Ana, Puača Gorana, Poša Mihalj
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Molecules. 2025 May 17;30(10):2197. doi: 10.3390/molecules30102197.
This study investigated the influence of β-cyclodextrin (βCD) on the micellization behavior of two bile salt surfactants, sodium deoxycholate (NaDC) and sodium cholate (NaC), in aqueous solutions. Tensiometry, conductometric, and spectrofluorimetric techniques were employed to determine critical micelle concentrations (CMCs) in the presence of varying concentrations of βCD, as well as in the presence of inorganic salts (NaCl and CsCl). The results showed that βCD forms inclusion complexes with both bile salts, leading to an increase in their CMCs, consistent with a competitive interaction between micelle formation and complexation. The inclusion constants, determined graphically, revealed stronger complexation for NaDC than NaC, attributed to differences in hydrophobic surface area. Salt addition decreased the CMC of both surfactants, with CsCl having a more pronounced effect. However, salt presence also modulated the inclusion complex formation, suggesting specific ion effects influence the availability and behavior of βCD. These findings contribute to the understanding of bile salt-cyclodextrin interactions and their modulation by electrolytes, with implications for drug delivery and supramolecular chemistry.
本研究考察了β-环糊精（βCD）对两种胆盐表面活性剂——脱氧胆酸钠（NaDC）和胆酸钠（NaC）——在水溶液中胶束化行为的影响。采用表面张力测定法、电导测定法和荧光光谱法等技术，测定了在不同浓度βCD以及无机盐（NaCl和CsCl）存在下的临界胶束浓度（CMC）。结果表明，βCD与两种胆盐均形成包合物，导致其CMC升高，这与胶束形成和络合之间的竞争相互作用一致。通过图形法测定的包合常数表明，NaDC的络合作用强于NaC，这归因于疏水表面积的差异。添加盐降低了两种表面活性剂的CMC，其中CsCl的影响更为显著。然而，盐的存在也调节了包合物的形成，表明特定离子效应影响βCD的可用性和行为。这些发现有助于理解胆盐-环糊精相互作用及其受电解质的调节，对药物递送和超分子化学具有重要意义。
