Yoshikiyo Keisuke, Shimizu Hidehisa, Okada Hitomi, Hasegawa Atsunori, Yamamoto Tatsuyuki
Institute of Agricultural and Life Sciences, Academic Assembly, Shimane University, 1060 Nishikawatsu-Cho, Matsue 690-8504, Shimane, Japan.
Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu-Cho, Matsue 690-8504, Shimane, Japan.
Int J Mol Sci. 2025 Aug 12;26(16):7776. doi: 10.3390/ijms26167776.
Perilla oil, a plant-derived lipid rich in α-linolenic acid (ALA), has demonstrated enhanced bioavailability when administered as an inclusion complex with γ-cyclodextrin (γ-CD). Crucially, it remains unclear whether this enhancement requires complex formation or can be achieved simply by co-ingestion. To address this, we compared the effects of a γ-CD-perilla oil inclusion complex to the effects of a physical mixture of the two on the plasma fatty acid profiles of rats fed these preparations for four weeks. Both treatment groups showed significant alterations in plasma fatty acid composition compared to the control group. Notably, our results indicated no significant differences between the inclusion complex and physical mixture groups. These findings suggest that γ-CD facilitates the intestinal absorption of perilla oil through co-ingestion, irrespective of its complexation status. This highlights the potential of γ-CD as a practical and effective delivery aid for improving the bioavailability of ALA-rich oils. Further studies are warranted to elucidate the underlying mechanisms and their applicability to human nutrition.
紫苏油是一种富含α-亚麻酸（ALA）的植物源脂质，当与γ-环糊精（γ-CD）形成包合物给药时，已证明其生物利用度有所提高。至关重要的是，目前尚不清楚这种提高是需要形成复合物，还是仅仅通过同时摄入就能实现。为了解决这个问题，我们比较了γ-CD-紫苏油包合物和两者物理混合物对喂食这些制剂四周的大鼠血浆脂肪酸谱的影响。与对照组相比，两个治疗组的血浆脂肪酸组成均有显著变化。值得注意的是，我们的结果表明包合物组和物理混合物组之间没有显著差异。这些发现表明，γ-CD通过同时摄入促进了紫苏油的肠道吸收，而与其络合状态无关。这突出了γ-CD作为提高富含ALA的油类生物利用度的实用有效递送助剂的潜力。有必要进一步研究以阐明其潜在机制及其在人类营养中的适用性。
