Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-093 Warsaw, Poland.
Int J Mol Sci. 2023 May 15;24(10):8780. doi: 10.3390/ijms24108780.
This review focuses on the methods of preparation and biological, physiochemical, and theoretical analysis of the inclusion complexes formed between estrogens and cyclodextrins (CDs). Because estrogens have a low polarity, they can interact with some cyclodextrins' hydrophobic cavities to create inclusion complexes, if their geometric properties are compatible. For the last forty years, estrogen-CD complexes have been widely applied in several fields for various objectives. For example, CDs have been used as estrogen solubilizers and absorption boosters in pharmaceutical formulations, as well as in chromatographic and electrophoretic procedures for their separation and quantification. Other applications include the removal of the endocrine disruptors from environmental materials, the preparation of the samples for mass spectrometric analysis, or solid-phase extractions based on complex formation with CDs. The aim of this review is to gather the most important outcomes from the works related to this topic, presenting the results of synthesis, in silico, in vitro, and in vivo analysis.
这篇综述重点介绍了雌激素与环糊精（CDs）形成包合物的制备方法以及生物、物理化学和理论分析。由于雌激素极性较低，因此如果其几何性质相容，它们可以与某些环糊精的疏水性空腔相互作用形成包合物。在过去的四十年中，雌激素-CD 复合物已广泛应用于多个领域的各种目标。例如，CD 已被用作药物制剂中雌激素的增溶剂和吸收促进剂，以及用于分离和定量的色谱和电泳程序。其他应用包括从环境材料中去除内分泌干扰物、为质谱分析制备样品或基于与 CDs 形成复合物的固相萃取。本综述的目的是汇集与该主题相关的最重要的研究成果，介绍合成、计算机模拟、体外和体内分析的结果。
