Stoyanova Nikoleta, Nachev Nasko, Georgieva Ani, Toshkova Reneta, Spasova Mariya
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, Bl. 103A, 1113 Sofia, Bulgaria.
Centre of Competence "Sustainable Utilization of Bio-Resources and Waste of Medicinal and Aromatic Plants for Innovative Bioactive Products" (BIORESOURCES BG), 1000 Sofia, Bulgaria.
Pharmaceutics. 2025 Apr 27;17(5):577. doi: 10.3390/pharmaceutics17050577.
The plant extract of quercetin possesses valuable pharmacological properties. However, its high instability, poor water solubility, and low cell bioavailability has limited its medical applications. An innovative approach used to overcome these limitations is the QUE incorporation in suitable polymer carriers. In the present study, fibrous materials based on PLA or PLA/PEG loaded with the flavonoid quercetin (QUE) were obtained by the electrospinning technique. Diverse morphological, spectroscopic, physico-mechanical, and spectrophotometric methods were used to characterize the prepared electrospun mats. The addition of hydrophilic PEG to the polymer matrix improved its wettability and assisted the more rapid release of QUE from the PLA/PEG fibrous mat than from the PLA one. The obtained fibrous mats possess good mechanical properties. Moreover, QUE-loaded electrospun mats exhibited high anticancer activity against HeLa cervical cancer cells, but lower toxicity to normal cells. The obtained perspective results revealed the potential of the obtained QUE-loaded materials to find applications for wound healing and cancer treatment.
槲皮素的植物提取物具有重要的药理特性。然而，其高不稳定性、低水溶性和低细胞生物利用度限制了其医学应用。一种用于克服这些局限性的创新方法是将槲皮素掺入合适的聚合物载体中。在本研究中，通过静电纺丝技术获得了基于聚乳酸（PLA）或聚乳酸/聚乙二醇（PLA/PEG）并负载黄酮类化合物槲皮素（QUE）的纤维材料。采用多种形态学、光谱学、物理力学和分光光度法对制备的静电纺丝垫进行表征。向聚合物基质中添加亲水性聚乙二醇提高了其润湿性，并有助于槲皮素从PLA/PEG纤维垫中比从PLA纤维垫中更快地释放出来。所获得的纤维垫具有良好的机械性能。此外，负载槲皮素的静电纺丝垫对人宫颈癌HeLa细胞表现出高抗癌活性，但对正常细胞的毒性较低。所获得的有前景的结果揭示了所获得的负载槲皮素材料在伤口愈合和癌症治疗方面的应用潜力。
