• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于牙周炎复合抗炎和抗菌治疗的水凝胶-纳米脂质制剂

Hydrogel-Nanolipid Formulations for the Complex Anti-Inflammatory and Antimicrobial Therapy of Periodontitis.

作者信息

Ashfaq Rabia, Tóth Nóra, Kovács Anita, Berkó Szilvia, Katona Gábor, Ambrus Rita, Polgár Tamás Ferenc, Szécsényi Mária, Burián Katalin, Budai-Szűcs Mária

机构信息

Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary.

Core Facility, HUN-REN Biological Research Centre, H-6726 Szeged, Hungary.

出版信息

Pharmaceutics. 2025 May 7;17(5):620. doi: 10.3390/pharmaceutics17050620.

DOI:10.3390/pharmaceutics17050620
PMID:40430912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12114638/
Abstract

: This study aimed to develop and evaluate nanostructured lipid carriers (NLCs) loaded with meloxicam (Melox) and a therapeutic antibacterial and anti-inflammatory liquid lipid, clove oil (CO) for periodontitis treatment, a complex inflammatory condition necessitating advanced drug delivery systems. The NLC-Melox formulation was integrated into three hydrogels, hypromellose (HPMC), zinc hyaluronate (ZnHA), and sodium hyaluronate (NaHA), to conduct a comparative analysis focusing on enhanced localized drug delivery, improved mucoadhesion, prolonged retention, and significant therapeutic outcomes. NLC-Melox was prepared by homogenization and characterized by dynamic light scattering (DLS). Subsequently, NLC-Melox-loaded gels were subjected to transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Raman spectroscopy, and rheological analysis. In vitro drug release, anti-inflammatory activity (BSA denaturation assay), and antibacterial efficacy (MIC, MBC) were investigated to assess therapeutic potential. DLS revealed a particle size of 183 nm with a polydispersity index of 0.26, indicating homogeneity. TEM confirmed consistent morphology and uniform nanoparticle distribution. DSC and XRD demonstrated the amorphous nature of Melox, enhancing solubility and stability. Spectroscopy confirmed no chemical interactions between components. Rheological studies identified ZnHA as the most mucoadhesive and structurally stable gel. In vitro release studies showed sustained drug release over 24 h. Melox and CO-loaded formulations demonstrated significant anti-inflammatory activity and notable antibacterial efficacy due to the antibacterial oil. The study highlighted the potential of NLC-based mucoadhesive hydrogels as an effective strategy for periodontitis treatment. The formulation offered improved drug solubility, therapeutic efficacy, mucoadhesivity, and prolonged delivery, making it a promising candidate for localized therapy.

摘要

本研究旨在开发和评估负载美洛昔康（Melox）以及治疗性抗菌和抗炎液态脂质丁香酚（CO）的纳米结构脂质载体（NLCs）用于治疗牙周炎，牙周炎是一种复杂的炎症性疾病，需要先进的药物递送系统。将NLC-Melox制剂整合到三种水凝胶中，即羟丙甲纤维素（HPMC）、透明质酸锌（ZnHA）和透明质酸钠（NaHA），以进行比较分析，重点关注增强局部药物递送、改善粘膜粘附性、延长滞留时间和显著的治疗效果。通过均质法制备NLC-Melox，并通过动态光散射（DLS）进行表征。随后，对负载NLC-Melox的凝胶进行透射电子显微镜（TEM）、差示扫描量热法（DSC）、X射线衍射（XRD）、拉曼光谱和流变学分析。研究体外药物释放、抗炎活性（牛血清白蛋白变性试验）和抗菌功效（MIC、MBC）以评估治疗潜力。DLS显示粒径为183 nm，多分散指数为0.26，表明具有均一性。TEM证实形态一致且纳米颗粒分布均匀。DSC和XRD证明美洛昔康为无定形性质，提高了溶解度和稳定性。光谱学证实各组分之间无化学相互作用。流变学研究确定ZnHA是粘膜粘附性最强且结构最稳定的凝胶。体外释放研究表明药物在24小时内持续释放。负载美洛昔康和丁香酚的制剂由于含有抗菌油而表现出显著的抗炎活性和显著的抗菌功效。该研究强调了基于NLC的粘膜粘附水凝胶作为牙周炎治疗有效策略的潜力。该制剂提高了药物溶解度、治疗功效、粘膜粘附性并延长了递送时间，使其成为局部治疗的有前景的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/09b53aa199a1/pharmaceutics-17-00620-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/0e7996c5d581/pharmaceutics-17-00620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/250c44161f2a/pharmaceutics-17-00620-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/abfa0c9154e7/pharmaceutics-17-00620-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/5aa06dbfb645/pharmaceutics-17-00620-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/8be72deadd9c/pharmaceutics-17-00620-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/9965861a656d/pharmaceutics-17-00620-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/9bdffddd0828/pharmaceutics-17-00620-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/d77e5e7c1071/pharmaceutics-17-00620-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/2b60890e9fac/pharmaceutics-17-00620-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/6a420f24e42e/pharmaceutics-17-00620-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/09b53aa199a1/pharmaceutics-17-00620-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/0e7996c5d581/pharmaceutics-17-00620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/250c44161f2a/pharmaceutics-17-00620-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/abfa0c9154e7/pharmaceutics-17-00620-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/5aa06dbfb645/pharmaceutics-17-00620-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/8be72deadd9c/pharmaceutics-17-00620-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/9965861a656d/pharmaceutics-17-00620-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/9bdffddd0828/pharmaceutics-17-00620-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/d77e5e7c1071/pharmaceutics-17-00620-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/2b60890e9fac/pharmaceutics-17-00620-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/6a420f24e42e/pharmaceutics-17-00620-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ae/12114638/09b53aa199a1/pharmaceutics-17-00620-g011.jpg

相似文献

1
Hydrogel-Nanolipid Formulations for the Complex Anti-Inflammatory and Antimicrobial Therapy of Periodontitis.用于牙周炎复合抗炎和抗菌治疗的水凝胶-纳米脂质制剂
Pharmaceutics. 2025 May 7;17(5):620. doi: 10.3390/pharmaceutics17050620.
2
Formulation and evaluation of lidocaine lipid nanosystems for dermal delivery.利多卡因脂质纳米系统的构建与评价及其经皮给药
AAPS PharmSciTech. 2009;10(3):985-92. doi: 10.1208/s12249-009-9287-1. Epub 2009 Jul 30.
3
Efficacy of umbelliferone-loaded nanostructured lipid carrier in the management of bleomycin-induced idiopathic pulmonary fibrosis: experimental and network pharmacology insight.载有伞形花内酯的纳米结构脂质载体在博来霉素诱导的特发性肺纤维化治疗中的疗效：实验和网络药理学见解
Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec 24. doi: 10.1007/s00210-024-03744-x.
4
Formulation and in vitro characterization of domperidone loaded solid lipid nanoparticles and nanostructured lipid carriers.多潘立酮固体脂质纳米粒和纳米结构脂质载体的制备及体外评价。
Daru. 2011;19(1):23-32.
5
Nanostructured Lipid Carriers (NLC)-Based Topical Formulation of Hesperidin for Effective Treatment of Psoriasis.基于纳米结构脂质载体（NLC）的橙皮苷局部制剂用于有效治疗银屑病
Pharmaceutics. 2025 Apr 7;17(4):478. doi: 10.3390/pharmaceutics17040478.
6
Assessing the Antibacterial Potential and Biofilm Inhibition Capability of Atorvastatin-Loaded Nanostructured Lipid Carriers via Crystal Violet Assay.通过结晶紫测定法评估载有阿托伐他汀的纳米结构脂质载体的抗菌潜力和生物膜抑制能力。
Pharmaceuticals (Basel). 2025 Mar 15;18(3):417. doi: 10.3390/ph18030417.
7
Development and characterization of a novel controlled release drug delivery system based on nanostructured lipid carriers gel for meloxicam.基于载药纳米结构脂质载体凝胶的美洛昔康新型控释给药系统的研制与评价。
Life Sci. 2013 Nov 13;93(21):763-72. doi: 10.1016/j.lfs.2013.09.027. Epub 2013 Oct 7.
8
Nanostructured-lipid carriers-Chitosan hydrogel beads carrier system for loading of resveratrol: A new method of topical application.用于负载白藜芦醇的纳米结构脂质载体-壳聚糖水凝胶珠载体系统：一种局部应用的新方法。
J Biomater Appl. 2022 Mar;36(8):1444-1457. doi: 10.1177/08853282211053923. Epub 2022 Jan 7.
9
Preparation and Characterization of Nanostructured Lipid Carriers (NLCs) Containing Extract for the Treatment of Skin Hyperpigmentation.载姜黄提取物的纳米结构脂质载体（NLC）的制备及表征及其在皮肤色素沉着治疗中的应用。
Curr Pharm Des. 2024;30(40):3213-3232. doi: 10.2174/0113816128327512240730102545.
10
Pharmacodynamic and Physicochemical Evaluation of Intranasal Zolmitriptan-Loaded Nanostructured Lipid Carriers: for Enhanced Antimigraine Potential.鼻内载佐米曲普坦纳米结构脂质载体的药效学和物理化学评价：用于增强抗偏头痛潜力
Assay Drug Dev Technol. 2025 May 26. doi: 10.1089/adt.2025.016.

本文引用的文献

1
evaluation of the mucoadhesive properties of zinc hyaluronate.透明质酸锌的黏膜黏附特性评估
Nat Prod Res. 2025 Feb 11:1-5. doi: 10.1080/14786419.2025.2463693.
2
Smart biomaterial gels for periodontal therapy: A novel approach.用于牙周治疗的智能生物材料凝胶：一种新方法。
Biomed Pharmacother. 2025 Feb;183:117836. doi: 10.1016/j.biopha.2025.117836. Epub 2025 Jan 19.
3
Development of a Multilayer Film Including the Soluble Eggshell Membrane Fraction for the Treatment of Oral Mucosa Lesions.用于治疗口腔黏膜病变的包含可溶性蛋壳膜组分的多层膜的研制。
Pharmaceutics. 2024 Oct 19;16(10):1342. doi: 10.3390/pharmaceutics16101342.
4
Design of experiment (DoE) of mucoadhesive valproic acid-loaded nanostructured lipid carriers (NLC) for potential nose-to-brain application.设计实验（DoE）的 mucoadhesive 负载纳米结构化脂质载体（NLC）的丙戊酸为潜在的鼻脑应用。
Int J Pharm. 2024 Oct 25;664:124631. doi: 10.1016/j.ijpharm.2024.124631. Epub 2024 Aug 29.
5
Formulation and Evaluation of Meloxicam Hybrid nano Particles.美洛昔康混合纳米粒子的制备与评价。
AAPS PharmSciTech. 2024 Jul 24;25(6):172. doi: 10.1208/s12249-024-02878-8.
6
Comparative Anti-inflammatory Activity of a Nanocomposite-Based Herbal Oral Rinse and a Commercial Oral Rinse.基于纳米复合材料的草本漱口水与市售漱口水的抗炎活性比较
Cureus. 2024 Jun 2;16(6):e61548. doi: 10.7759/cureus.61548. eCollection 2024 Jun.
7
Estimation of MBC: MIC Ratio of Herbal Extracts against Common Endodontic Pathogens.草药提取物对常见牙髓病病原体的最低杀菌浓度（MBC）与最低抑菌浓度（MIC）比值的测定
J Pharm Bioallied Sci. 2024 Apr;16(Suppl 2):S1414-S1416. doi: 10.4103/jpbs.jpbs_735_23. Epub 2024 Apr 16.
8
Binary Mixtures of Meloxicam and L-Tartaric Acid for Oral Bioavailability Modulation of Pharmaceutical Dosage Forms.用于调节药物剂型口服生物利用度的美洛昔康与L-酒石酸二元混合物
J Funct Biomater. 2024 Apr 16;15(4):104. doi: 10.3390/jfb15040104.
9
The Incorporation of Clove Essential Oil into Nanostructured Lipid Carrier for Improvement of the Delivery and Antioxidant Effects on the Fibroblast Cells.将丁香精油掺入纳米结构脂质载体以改善其对成纤维细胞的递送及抗氧化作用
Pharm Nanotechnol. 2025;13(2):372-382. doi: 10.2174/0122117385304491240320040711.
10
Comparative Anti-inflammatory Activity of Silver and Zinc Oxide Nanoparticles Synthesized Using Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulations.使用罗勒和甜罗勒草药配方合成的银和氧化锌纳米颗粒的抗炎活性比较
Cureus. 2024 Jan 26;16(1):e52995. doi: 10.7759/cureus.52995. eCollection 2024 Jan.