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一种新型牛乳铁蛋白衍生肽对大鼠肠道形态和肠道菌群的影响

Effects of a Novel Bovine Lactoferrin-Derived Peptide on the Intestinal Morphology and Intestinal Flora in Rats.

作者信息

Huang Tianle, Yang Huan, Zhao Yang, Cui Haiyue, Qi Xiaoxi, Miao Liguang

机构信息

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.

出版信息

Microorganisms. 2025 Apr 24;13(5):975. doi: 10.3390/microorganisms13050975.

DOI:10.3390/microorganisms13050975
PMID:40431148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12114612/
Abstract

Bovine lactoferrin-derived peptide LF-MQL was administered to healthy rats to assess its effects on growth parameters and gut morphology. Faecal samples were analysed by 16S rRNA high-throughput sequencing to investigate the modulatory effects of LF-MQL on the composition and diversity of the gut microbiota. The results showed that both experimental groups maintained intact intestinal organization. Notably, supplementation with LF-MQL significantly increased the length of small intestinal villi compared to the control group ( < 0.05), and an improvement in the structural organization of the villi, including a more ordered and compact arrangement, was observed. These morphological findings suggest that there are no adverse effects associated with LF-MQL administration. In addition, administration of LF-MQL modulates the functional activity of the gut microbiota and regulates their involvement in host-related metabolic pathways, thereby improving gut homeostasis. These findings provide a theoretical basis for evaluating the safety of bovine lactoferrin peptides in food and pharmaceutical applications.

摘要

将源自牛乳铁蛋白的肽LF-MQL给予健康大鼠，以评估其对生长参数和肠道形态的影响。通过16S rRNA高通量测序分析粪便样本，以研究LF-MQL对肠道微生物群组成和多样性的调节作用。结果表明，两个实验组的肠道组织均保持完整。值得注意的是，与对照组相比，补充LF-MQL显著增加了小肠绒毛的长度（<0.05），并且观察到绒毛的结构组织有所改善，包括排列更有序和紧密。这些形态学结果表明，给予LF-MQL没有相关的不良影响。此外，给予LF-MQL可调节肠道微生物群的功能活性，并调节它们参与宿主相关代谢途径，从而改善肠道稳态。这些发现为评估牛乳铁蛋白肽在食品和制药应用中的安全性提供了理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/720960f43592/microorganisms-13-00975-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/1540c998a195/microorganisms-13-00975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/b1ec2a82acc9/microorganisms-13-00975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/bb042eb6b599/microorganisms-13-00975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/6b1eb20d1f8a/microorganisms-13-00975-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/9b991943cf39/microorganisms-13-00975-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/2c24a5de3226/microorganisms-13-00975-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/cd8b30a31b13/microorganisms-13-00975-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/18f30e50f636/microorganisms-13-00975-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/31b4f76aff03/microorganisms-13-00975-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/fa7016e1e86f/microorganisms-13-00975-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/720960f43592/microorganisms-13-00975-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/1540c998a195/microorganisms-13-00975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/b1ec2a82acc9/microorganisms-13-00975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/bb042eb6b599/microorganisms-13-00975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/6b1eb20d1f8a/microorganisms-13-00975-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/9b991943cf39/microorganisms-13-00975-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/2c24a5de3226/microorganisms-13-00975-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/cd8b30a31b13/microorganisms-13-00975-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/18f30e50f636/microorganisms-13-00975-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/31b4f76aff03/microorganisms-13-00975-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/fa7016e1e86f/microorganisms-13-00975-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc8/12114612/720960f43592/microorganisms-13-00975-g011.jpg

相似文献

[1]
Effects of a Novel Bovine Lactoferrin-Derived Peptide on the Intestinal Morphology and Intestinal Flora in Rats.

Microorganisms. 2025-4-24

[2]
Immunologic Effects of a Novel Bovine Lactoferrin-Derived Peptide on the Gut and Clinical Perspectives.

Vet Sci. 2024-11-6

[3]
Lactoferrin up-regulates intestinal gene expression of brain-derived neurotrophic factors BDNF, UCHL1 and alkaline phosphatase activity to alleviate early weaning diarrhea in postnatal piglets.

J Nutr Biochem. 2014-8

[4]
Effects of lactoferrin on intestinal flora of metabolic disorder mice.

BMC Microbiol. 2022-7-22

[5]
Effects of early-life lactoferrin intervention on growth performance, small intestinal function and gut microbiota in suckling piglets.

Food Funct. 2019-8-8

[6]
Oral administration of lactoferrin attenuates intestinal ischemia-reperfusion injury in rats.

Eur Surg Res. 2012

[7]
Lactoferrin alleviates chronic low‑grade inflammation response in obese mice by regulating intestinal flora.

Mol Med Rep. 2024-8

[8]
Effects of Transglutaminase-Induced β-Conglycinin Gels on Intestinal Morphology and Intestinal Flora in Mice at Different High-Intensity Ultrasound Pretreatment Time.

Foods. 2024-7-11

[9]
Fecal 16S rRNA Gene Sequencing Analysis of Changes in the Gut Microbiota of Rats with Low-Dose Aspirin-Related Intestinal Injury.

Biomed Res Int. 2021

[10]
Early-life lactoferrin intervention modulates the colonic microbiota, colonic microbial metabolites and intestinal function in suckling piglets.

Appl Microbiol Biotechnol. 2020-7

本文引用的文献

[1]
Immunologic Effects of a Novel Bovine Lactoferrin-Derived Peptide on the Gut and Clinical Perspectives.

Vet Sci. 2024-11-6

[2]
Lactoferrin alleviates chronic low‑grade inflammation response in obese mice by regulating intestinal flora.

Mol Med Rep. 2024-8

[3]
Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review.

Foods. 2024-1-2

[4]
Rice Water-Fried Atractylodis Rhizoma Relieves Spleen Deficiency Diarrhea by Regulating the Intestinal Microbiome.

Oxid Med Cell Longev. 2023

[5]
Effects of lactoferrin on intestinal flora of metabolic disorder mice.

BMC Microbiol. 2022-7-22

[6]
Impacts of changes in intestinal flora on the metabolism of rats.

Bioengineered. 2021-12

[7]
Lactoferrin from Bovine Milk: A Protective Companion for Life.

Nutrients. 2020-8-24

[8]
Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation.

Nutrients. 2018-10-13

[9]
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.

Immunol Rev. 2017-9

[10]
Fecal microbiota variation across the lifespan of the healthy laboratory rat.

Gut Microbes. 2017-6-6

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