Shenhav Simon, Tsur Shenhav Leah, Gefel Dov, Rosen Shani R, Shenhav Amit, Shapin Rachel, Anteby Eyal Y, Ovadia Yaniv S
Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon 7830604, Israel.
Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba 8410501, Israel.
Nutrients. 2025 May 9;17(10):1624. doi: 10.3390/nu17101624.
: Iodine deficiency disorders remain a global public health concern, as acknowledged by the World Health Organization (WHO). Adequate maternal iodine intake during pregnancy is essential for normal fetal development, yet the relationship between maternal iodine status and fetal growth remains controversial. Urinary Iodine Concentration (UIC) is a commonly used marker for assessing iodine status. This study evaluates the association between maternal UIC and neonatal anthropometric parameters. : This prospective single-center cohort study included 202 pregnant women without known or reported thyroid disease, recruited between 2018 and 2021. Maternal iodine status was assessed by UIC from spot urine samples collected at the time of recruitment. Correlations were analyzed between maternal UIC and neonatal anthropometric measures, including birth weight (g), length (cm), and head circumference (cm). Analyses stratified by fetal sex were also performed. : No statistically significant association was found between UIC and neonatal anthropometric measures. Analysis of these correlations, stratified by fetal sex, did not reveal any statistically significant associations either. : Maternal UIC showed no association with neonatal anthropometric outcomes in this study, regardless of fetal sex. Further research is needed to investigate the additional effects of maternal iodine status in healthy, euthyroid pregnant women on neonatal outcomes.
世界卫生组织（WHO）承认，碘缺乏病仍然是一个全球公共卫生问题。孕期母亲摄入足够的碘对胎儿正常发育至关重要，但母亲碘状态与胎儿生长之间的关系仍存在争议。尿碘浓度（UIC）是评估碘状态常用的指标。本研究评估母亲UIC与新生儿人体测量参数之间的关联。 这项前瞻性单中心队列研究纳入了2018年至2021年间招募的202名无已知或报告甲状腺疾病的孕妇。在招募时通过即时尿样的UIC评估母亲的碘状态。分析母亲UIC与新生儿人体测量指标之间的相关性，包括出生体重（克）、身长（厘米）和头围（厘米）。还按胎儿性别进行了分层分析。 UIC与新生儿人体测量指标之间未发现统计学上显著的关联。按胎儿性别分层对这些相关性进行分析，也未发现任何统计学上显著的关联。 在本研究中，无论胎儿性别如何，母亲UIC与新生儿人体测量结果均无关联。需要进一步研究以调查健康、甲状腺功能正常的孕妇碘状态对新生儿结局的其他影响。
