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甜饮,酸涩后果:含糖饮料对精子健康的影响,一篇叙述性综述

Sweet Drinks, Sour Consequences: The Impact of Sugar-Sweetened Beverages on Sperm Health, a Narrative Review.

作者信息

Win Winnie Khine Yi, Wong Maverick Wenhao, Benny Paula, Huang Zhongwei

机构信息

Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.

Department of Obstetrics and Gynecology, National University Hospital Singapore, Singapore 119077, Singapore.

出版信息

Nutrients. 2025 May 20;17(10):1733. doi: 10.3390/nu17101733.

Abstract

The rising global consumption of sugar-sweetened beverages (SSBs) has paralleled a concerning decline in sperm quality, raising concern about potential dietary impacts on male fertility. Sperm health parameters, including count, motility, and morphology, are critical indicators of reproductive potential and may be adversely affected by excessive sugar intake. This narrative review consolidates the current evidence on the association between SSB consumption and sperm health, highlighting potential biological mechanisms. A targeted literature search across PubMed, Scopus, and Google Scholar was conducted, utilising keywords "sugar-sweetened beverages", "sperm health", and related terms. A total of 11 eligible observational and cohort studies were selected. Studies focusing solely on animal models or unrelated dietary factors were excluded. The primary research consistently reports a negative association between high SSB consumption and sperm parameters, including reduced count and motility, and increased DNA fragmentation. Potential mechanisms include oxidative stress, hormonal dysregulation, and metabolic dysfunction linked to obesity and insulin resistance. However, variability in study design, exposure assessment, and population demographics limits generalisability of the results. The current evidence suggests that regular SSB consumption adversely affects male reproductive health through oxidative damage and hormonal imbalances. These findings underscore the importance of public health strategies to reduce SSB intake, especially among young men of reproductive age. Further longitudinal studies with standardised methodologies, particularly in underrepresented populations such as Asian cohorts, are necessary to establish causal relationships and guide clinical recommendations.

摘要

全球含糖饮料(SSB)消费量的上升与令人担忧的精子质量下降同时出现,这引发了人们对饮食对男性生育能力潜在影响的关注。精子健康参数,包括数量、活力和形态,是生殖潜力的关键指标,可能会受到过量糖摄入的不利影响。这篇叙述性综述整合了关于饮用含糖饮料与精子健康之间关联的现有证据,突出了潜在的生物学机制。利用关键词“含糖饮料”、“精子健康”及相关术语,在PubMed、Scopus和谷歌学术上进行了有针对性的文献检索。共筛选出11项符合条件的观察性研究和队列研究。仅关注动物模型或不相关饮食因素的研究被排除。主要研究一致报告,高含糖饮料消费量与精子参数之间存在负相关,包括数量减少、活力降低以及DNA碎片化增加。潜在机制包括氧化应激、激素失调以及与肥胖和胰岛素抵抗相关的代谢功能障碍。然而,研究设计、暴露评估和人群特征方面的差异限制了结果的普遍性。目前的证据表明,经常饮用含糖饮料会通过氧化损伤和激素失衡对男性生殖健康产生不利影响。这些发现强调了公共卫生策略在减少含糖饮料摄入量方面的重要性,尤其是在育龄年轻男性中。需要进一步开展采用标准化方法的纵向研究,特别是在亚洲人群等代表性不足的人群中,以建立因果关系并指导临床建议。

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