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COPII转运复合体参与人乳头瘤病毒16型感染。

The COPII Transport Complex Participates in HPV16 Infection.

作者信息

Day Patricia M, Thompson Cynthia D, Weisberg Andrea S, Schiller John T

机构信息

Laboratory of Cellular Oncology, NCI, NIH, Bethesda, MD 20892, USA.

Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA.

出版信息

Viruses. 2025 Apr 25;17(5):616. doi: 10.3390/v17050616.

Abstract

Human papillomavirus (HPV) 16 is transported in a retrograde fashion from the cell surface to the Golgi apparatus. Prior to mitosis, the virus loses association with the Golgi and, following nuclear envelope breakdown, is found associated with the condensed mitotic chromatin. The intervening steps have not been well defined. It was previously demonstrated that the virus is transported to the mitotic chromosomes in vesicles. Here, we describe the role of the endoplasmic reticulum (ER) in the post-Golgi trafficking and the importance of the ER-generated coat protein complex II (COPII) anterograde trafficking pathway in HPV infection. HPV pseudovirus (PsV) colocalized with COPII components and silencing of this pathway inhibited HPV infection. Additionally, the inner COPII coat protein, Sec24b, could be biochemically isolated in association with HPV capsid proteins. This study provides insight into the mechanism of post-Golgi HPV trafficking.

摘要

人乳头瘤病毒16型(HPV 16)以逆行方式从细胞表面转运至高尔基体。在有丝分裂之前,该病毒与高尔基体失去关联,并且在核膜破裂后,发现其与浓缩的有丝分裂染色质相关联。中间步骤尚未明确界定。先前已证明该病毒通过囊泡转运至有丝分裂染色体。在此,我们描述了内质网(ER)在高尔基体后转运中的作用以及ER产生的II型被膜蛋白复合物(COPII)顺行转运途径在HPV感染中的重要性。HPV假病毒(PsV)与COPII组分共定位,并且该途径的沉默抑制了HPV感染。此外,可通过生化方法分离出与HPV衣壳蛋白相关的COPII内被膜蛋白Sec24b。本研究为高尔基体后HPV转运机制提供了见解。

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