Kasianov Nikita, Sharshov Kirill, Derko Anastasiya, Sobolev Ivan, Dubovitskiy Nikita, Loginova Arina, Shemyakin Evgeniy, Vladimirtseva Maria, Egorov Nikolay, Gabyshev Viacheslav, Kim Yujin, Lee Sun-Hak, Cho Andrew Y, Kim Deok-Hwan, Kim Tae-Hyeon, Song Chang-Seon, Jeong Hyesung, Jheong Weonhwa, Hong Yoonjee, Mine Junki, Uchida Yuko, Tsunekuni Ryota, Saito Takehiko, Shestopalov Alexander
Federal Research Center of Fundamental and Translational Medicine, Siberian Branch, Russian Academy of Sciences (FRC FTM SB RAS,), Novosibirsk 630060, Russia.
Institute of Biological Problems of the Cryolithozone, Siberian Branch, Russian Academy of Sciences, Yakutsk 677980, Russia.
Viruses. 2025 Apr 27;17(5):632. doi: 10.3390/v17050632.
Yakutia, the largest breeding ground for wild migratory birds in Northeastern Siberia, plays a big role in the global ecology of avian influenza viruses (AIVs). In this study, we present the results of virological surveillance conducted between 2018 and 2023, analyzing 1970 cloacal swab samples collected from 56 bird species. We identified 74 AIVs of H3N6, H3N8, H4N6, H5N3, H7N7, H10N3, and H11N9 subtypes in Anseriformes order. Phylogenetic analysis showed that the isolates belong to the Eurasian lineage and have genetic similarities with strains from East Asia, Europe, and North America. Cluster analysis has demonstrated the circulation of stable AIV genotypes for several years. We assume that Yakutia is an important territory for viral exchange on the migratory routes of migrating birds. In addition, several amino acid substitutions have been found to be associated with increased virulence and adaptation to mammalian hosts, highlighting the potential risk of interspecific transmission. These results provide a critical insight into the ecology of the AIV and highlight the importance of continued monitoring in this geographically significant region.
雅库特地区是西伯利亚东北部最大的野生候鸟繁殖地，在禽流感病毒（AIVs）的全球生态中发挥着重要作用。在本研究中，我们展示了2018年至2023年期间进行的病毒学监测结果，分析了从56种鸟类收集的1970份泄殖腔拭子样本。我们在雁形目鸟类中鉴定出了H3N6、H3N8、H4N6、H5N3、H7N7、H10N3和H11N9亚型的74种禽流感病毒。系统发育分析表明，分离株属于欧亚谱系，与来自东亚、欧洲和北美的毒株具有遗传相似性。聚类分析表明，稳定的禽流感病毒基因型已经传播了数年。我们认为，雅库特地区是候鸟迁徙路线上病毒交换的重要区域。此外，还发现了一些与毒力增加和对哺乳动物宿主适应性相关的氨基酸替换，突出了种间传播的潜在风险。这些结果为禽流感病毒的生态学提供了重要见解，并强调了在这一具有地理意义的地区持续监测的重要性。
