慢性恰加斯病中的细胞免疫。
Cellular immunity in chronic Chagas' disease.
作者信息
Montufar O M, Musatti C C, Mendes E, Mendes N F
出版信息
J Clin Microbiol. 1977 Apr;5(4):401-4. doi: 10.1128/jcm.5.4.401-404.1977.
The cellular immune response was assessed in 20 patients with chronic Chagas' disease (American trypanosomiasis). Thymus-derived lymphocyte function was determined in vivo by cutaneous reactivity to several antigens including a soluble preparation derived from Trypanosoma cruzi and sensitization to 2,4-dinitrochlorobenzene. The in vitro T-cell reactivity was investigated by the proliferative response to phytohemagglutinin and to T. cruzi antigen and by inhibition of leukocyte migration with the specific antigen. In addition, the proportion and absolute numbers of peripheral blood T and B-lymphocytes were determined by rosette formation. This research indicates that the general and specific cellular immune response, evaluated by the tests herein mentioned, is well preserved in patients, with Chagas' disease. We conclude that chronic Chagas' disease is not associated with deficiency in cellular immunity, nor does it lead to it. Conceivably, the active participation of delayed hypersensitivity may play an important role in the expression of the human chagasic lesions.
对20例慢性恰加斯病（美洲锥虫病）患者的细胞免疫反应进行了评估。通过对几种抗原（包括源自克氏锥虫的可溶性制剂）的皮肤反应性以及对2,4 - 二硝基氯苯的致敏作用，在体内测定胸腺衍生淋巴细胞的功能。通过对植物血凝素和克氏锥虫抗原的增殖反应以及用特异性抗原抑制白细胞迁移，研究体外T细胞反应性。此外，通过玫瑰花结形成测定外周血T淋巴细胞和B淋巴细胞的比例及绝对数量。本研究表明，通过本文所述测试评估的一般和特异性细胞免疫反应在恰加斯病患者中保存良好。我们得出结论，慢性恰加斯病与细胞免疫缺陷无关，也不会导致细胞免疫缺陷。可以想象，迟发型超敏反应的积极参与可能在人类恰加斯病病变的表现中起重要作用。
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