恰加斯病患者的淋巴细胞会对心脏抗原产生反应吗？
Do lymphocytes from Chagasic patients respond to heart antigens?
作者信息
Todd C W, Todd N R, Guimaraes A C
出版信息
Infect Immun. 1983 May;40(2):832-5. doi: 10.1128/iai.40.2.832-835.1983.
Abstract
Lymphocyte transformation studies of nonadherent lymphocytes from chronic Chagasic and uninfected persons demonstrated that responses of all individuals to a mouse heart homogenate showed a correlation with responses to streptococcal antigens. Considering the known cross-reactions between streptococcal and cardiac antigens and the high reactivity of Chagasic patients to streptococcal antigens, it is possible that positive lymphocyte transformation to unfractionated heart antigen preparations may not represent specific reactivity to heart antigens.
摘要
对慢性恰加斯病患者和未感染人群的非黏附淋巴细胞进行的淋巴细胞转化研究表明，所有个体对小鼠心脏匀浆的反应与对链球菌抗原的反应存在相关性。鉴于已知链球菌抗原与心脏抗原之间存在交叉反应，且恰加斯病患者对链球菌抗原具有高反应性，对未分级心脏抗原制剂的淋巴细胞转化呈阳性可能并不代表对心脏抗原的特异性反应。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC FEVER, AND GLOMERULONEPHRITIS.链球菌与组织抗原的免疫关系。III. 人血清中与心脏组织发生交叉反应的链球菌抗体的存在。与链球菌感染、风湿热和肾小球肾炎的关联。
J Exp Med. 1964 Apr 1;119(4):651-66. doi: 10.1084/jem.119.4.651.
3
Immune response in human Chagas disease II. Lymphocyte blastogenesis in patients with chagasic cardiomyopathy.
Acta Cient Venez. 1980;31(5):464-7.
4
Chagas' disease: selective affinity and cytotoxicity of Trypanosoma cruzi-immune lymphocytes to parasympathetic ganglion cells.
Mem Inst Oswaldo Cruz. 1980 Jul-Dec;75(3-4):33-45. doi: 10.1590/s0074-02761980000200004.
5
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6
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Nature. 1982 Mar 4;296(5852):34-8. doi: 10.1038/296034a0.
7
Post-nephrectomy arteriovenous fistula.
J Urol. 1967 Jul;98(1):44-7. doi: 10.1016/S0022-5347(17)62820-9.
8
The immunology of experimental Chagas' disease. 3. Rejection of allogeneic heart cells in vitro.实验性恰加斯病的免疫学。3. 体外同种异体心脏细胞的排斥反应。
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9
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Circulation. 1974 Jan;49(1):13-21. doi: 10.1161/01.cir.49.1.13.
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