恰加斯病患者的淋巴细胞会对心脏抗原产生反应吗？
Do lymphocytes from Chagasic patients respond to heart antigens?
作者信息
Todd C W, Todd N R, Guimaraes A C
出版信息
Infect Immun. 1983 May;40(2):832-5. doi: 10.1128/iai.40.2.832-835.1983.
Abstract
Lymphocyte transformation studies of nonadherent lymphocytes from chronic Chagasic and uninfected persons demonstrated that responses of all individuals to a mouse heart homogenate showed a correlation with responses to streptococcal antigens. Considering the known cross-reactions between streptococcal and cardiac antigens and the high reactivity of Chagasic patients to streptococcal antigens, it is possible that positive lymphocyte transformation to unfractionated heart antigen preparations may not represent specific reactivity to heart antigens.
摘要
对慢性恰加斯病患者和未感染人群的非黏附淋巴细胞进行的淋巴细胞转化研究表明，所有个体对小鼠心脏匀浆的反应与对链球菌抗原的反应存在相关性。鉴于已知链球菌抗原与心脏抗原之间存在交叉反应，且恰加斯病患者对链球菌抗原具有高反应性，对未分级心脏抗原制剂的淋巴细胞转化呈阳性可能并不代表对心脏抗原的特异性反应。
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