Frithz G, Ronquist G, Ericsson P
Eur J Cancer Clin Oncol. 1985 Aug;21(8):913-7. doi: 10.1016/0277-5379(85)90107-5.
A significant elevation of serum sialyltransferase and fucosyltransferase mean activities was observed in 19 untreated patients with multiple myeloma. However, sialyltransferase mean activity was significantly lower in 13 other patients treated for 1-30 months with alkylating drugs and prednisolone. Such a definite decrease in serum enzyme activity on treatment was not recorded for fucosyltransferase. Instead, this activity was significantly increased in treated patients as compared to controls. The presenting clinical features of the 32 patients with multiple myeloma were the basis for a clinical staging system with regard to myeloma cell burden according to established criteria. In untreated patients (as opposed to treated ones), a significantly higher serum sialyltransferase (but not fucosyltransferase) activity was obtained among those 11 belonging to stage III than among the other eight with stages I and II, suggesting a link between tumour burden and enzyme activity. This assumption was further strengthened in those six patients followed lengthwise with regard to serum sialyltransferase activity. Concomitantly with objective evidence of change in tumour burden they showed corresponding alterations in sialyltransferase activity. The determination of sialyltransferase and fucosyltransferase activity in serum may be an additional contribution to refine initial assessment and follow-up of individual patients with multiple myeloma.
在19例未经治疗的多发性骨髓瘤患者中，观察到血清唾液酸转移酶和岩藻糖基转移酶的平均活性显著升高。然而，在另外13例接受烷化剂和泼尼松龙治疗1 - 30个月的患者中，唾液酸转移酶的平均活性显著降低。岩藻糖基转移酶在治疗过程中未出现血清酶活性的明显下降。相反，与对照组相比，治疗患者的该活性显著增加。32例多发性骨髓瘤患者的临床表现是根据既定标准对骨髓瘤细胞负荷进行临床分期系统的基础。在未经治疗的患者（与治疗患者相反）中，III期的11例患者血清唾液酸转移酶（而非岩藻糖基转移酶）活性显著高于I期和II期的其他8例患者，提示肿瘤负荷与酶活性之间存在联系。这一假设在6例随访血清唾液酸转移酶活性的患者中得到进一步加强。随着肿瘤负荷变化的客观证据出现，他们的唾液酸转移酶活性也出现相应改变。测定血清中唾液酸转移酶和岩藻糖基转移酶活性可能有助于完善对多发性骨髓瘤个体患者的初始评估和随访。
