Ip C, Dao T
Cancer Res. 1978 Mar;38(3):723-8.
We have measured sialyltransferase, galactosyltransferase, and fucosyltransferase as sell as 5'-nucleotidase in the serum of breast cancer patients. Serum sialyltransferase values in 65 normal healthy females ranged from 2.6 to 8.5 units, with a mean of 5.4. In 25 women with operable primary breast cancer, serum sialyltransferase levels were found to be between 6.2 and 15.4 units. Marked elevation of this enzyme level (range, 8.8 to 36 units) was observed in 48 patients with metastatic breast cancer. Galactosyltransferase and fucosyltransferase measurements, however, showed considerable overlap between the controls and the cancer patients. On the other hand serum 5'-nucleotidase and sialyltransferase in breast cancer patients showed very similar patterns. Thus, serum 5'-nucleotidase values in 44 normal females ranged from 11.4 to 23.2 units, whereas the levels found in 30 patients with metastasis were between 25 and 71.8 units. The tissue origin of abnormal levels of serum glycosyltransferases and 5'-nucleotidase was discussed in relation to their physiological significance as well as their role as markers for diagnosing early malignant breast neoplasm and for monitoring the extent of metastasis.
我们检测了乳腺癌患者血清中的唾液酸转移酶、半乳糖基转移酶、岩藻糖基转移酶以及5'-核苷酸酶。65名正常健康女性的血清唾液酸转移酶值在2.6至8.5单位之间，平均为5.4。在25名可手术的原发性乳腺癌女性患者中，血清唾液酸转移酶水平在6.2至15.4单位之间。在48名转移性乳腺癌患者中观察到该酶水平显著升高（范围为8.8至36单位）。然而，半乳糖基转移酶和岩藻糖基转移酶的检测结果显示，对照组和癌症患者之间存在相当大的重叠。另一方面，乳腺癌患者的血清5'-核苷酸酶和唾液酸转移酶表现出非常相似的模式。因此，44名正常女性的血清5'-核苷酸酶值在11.4至23.2单位之间，而在30名转移患者中发现的水平在25至71.8单位之间。我们讨论了血清糖基转移酶和5'-核苷酸酶异常水平的组织来源，及其生理意义，以及它们作为早期恶性乳腺肿瘤诊断标志物和转移程度监测指标的作用。
