Iio A, Strober W, Broder S, Polmar S H
J Clin Invest. 1977 May;59(5):743-55. doi: 10.1172/JCI108695.
Serum IgE concentrations were determined and IgE turnover studies were performed in control individuals as well as in patients with several disease states. Patients with common variable hypogammaglobulinemia, thymoma and hypogammaglobulinemia, ataxia telangiectasia, and selective IgA deficiency had significantly decreased mean serum IgE concentrations. In turnover studies, this was found to be due to decreased IgE synthesis. In spite of these depressed mean values, some patients with common variable hypogammaglobulinemia had normal serum IgE concentrations and synthetic rates. Patients with the Wiskott-Aldrich syndrome had a significantly elevated mean serum IgE concentration. In one of four patients studied with the turnover technique, a strikingly high IgE concentration was present and was associated with an elevated IgE synthetic rate. Three other patients had both normal serum IgE concentrations and synthetic rates. Patients with chronic lymphocytic leukemia had significantly decreased mean serum concentrations and synthetic rates for IgE. The depressed IgE synthesis was associated with a significantly prolonged IgE half-life. Patients with Hodgkin's disease had significantly increased serum IgE concentrations. One of three patients studied had a high serum IgE concentration and synthetic rate of IgE. The two other patients had normal serum IgE concentrations associated with normal synthetic rates. Finally patients with protein-losing enteropathy or familial hypercatabolic hypoproteinemia had normal IgE concentrations associated with normal IgE metabolic parameters. In these cases, the disorder in the catabolic rate was not severe enough to affect the total amount of circulating IgE because IgE normally has a very high fractional catabolic rate. In general, IgE levels in a variety of disease states were correlated with IgE synthetic rates and abnormalities in the catabolic rate of IgE in disease did not exert an important effect on IgE concentration.
测定了对照组个体以及患有多种疾病状态患者的血清IgE浓度，并进行了IgE周转率研究。患有常见变异型低丙种球蛋白血症、胸腺瘤伴低丙种球蛋白血症、共济失调毛细血管扩张症和选择性IgA缺乏症的患者，其平均血清IgE浓度显著降低。在周转率研究中，发现这是由于IgE合成减少所致。尽管这些平均值较低，但一些患有常见变异型低丙种球蛋白血症的患者血清IgE浓度和合成率正常。患有维斯科特-奥尔德里奇综合征的患者平均血清IgE浓度显著升高。在用周转率技术研究的4名患者中，有1名患者的IgE浓度极高，且与IgE合成率升高有关。其他3名患者的血清IgE浓度和合成率均正常。慢性淋巴细胞白血病患者的IgE平均血清浓度和合成率显著降低。IgE合成减少与IgE半衰期显著延长有关。霍奇金病患者的血清IgE浓度显著升高。在研究的3名患者中，有1名患者的血清IgE浓度和IgE合成率较高。另外2名患者的血清IgE浓度正常，合成率也正常。最后，患有蛋白丢失性肠病或家族性高分解代谢性低蛋白血症的患者IgE浓度正常，IgE代谢参数也正常。在这些情况下，分解代谢率的紊乱程度不足以影响循环IgE的总量，因为IgE通常具有非常高的分数分解代谢率。一般来说，多种疾病状态下的IgE水平与IgE合成率相关，疾病中IgE分解代谢率的异常对IgE浓度没有重要影响。
