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Waking Salivary Cortisone vs Serum Cortisol in the Short Synacthen Test in Screening for Adrenocortical Insufficiency: Results of a Service Evaluation.

作者信息

Heald Adrian, Mordaunt Mathilde, Gallant Natalie, Baker Hannah, Majeed Waseem, Kochhar Rupinder, Syed Akheel A, Mudaliar Rajshekhar, Abushufa Ramadan, Hanna Fahmy, Marshall David, Laing Ian, Keevil Brian, Fryer Anthony A

机构信息

University of Manchester, Manchester, UK.

Salford Royal Hospital, Salford, UK.

出版信息

Clin Endocrinol (Oxf). 2025 Sep;103(3):396-400. doi: 10.1111/cen.15279. Epub 2025 May 27.

DOI:10.1111/cen.15279
PMID:40432285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12319285/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60e/12319285/c43644ad1128/CEN-103-396-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60e/12319285/c43644ad1128/CEN-103-396-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60e/12319285/c43644ad1128/CEN-103-396-g001.jpg

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1
Waking Salivary Cortisone vs Serum Cortisol in the Short Synacthen Test in Screening for Adrenocortical Insufficiency: Results of a Service Evaluation.短程促肾上腺皮质激素试验中醒时唾液皮质醇与血清皮质醇用于筛查肾上腺皮质功能不全的比较：一项服务评估结果
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2
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Ann Clin Biochem. 2020 Nov;57(6):456-460. doi: 10.1177/0004563220961745. Epub 2020 Oct 13.
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Real world evidence supports waking salivary cortisone as a screening test for adrenal insufficiency.真实世界证据支持唾液皮质醇唤醒试验作为肾上腺皮质功能减退症的筛查试验。
Clin Endocrinol (Oxf). 2023 Dec;99(6):517-524. doi: 10.1111/cen.14975. Epub 2023 Oct 11.
4
Salivary cortisol and cortisone responses to tetracosactrin (synacthen).唾液皮质醇和可的松对二十四肽促皮质素（合成促皮质素）的反应。
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Use of salivary cortisol and cortisone in the high- and low-dose synacthen test.促肾上腺皮质激素高、低剂量同步试验中唾液皮质醇和皮质酮的应用。
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J Endocr Soc. 2017 Jan 13;1(2):96-108. doi: 10.1210/js.2016-1056. eCollection 2017 Feb 1.
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Salivary Cortisol and Cortisone Can Circumvent Confounding Effects of Oral Contraceptives in the Short Synacthen Test.唾液皮质醇和皮质酮可绕过短期 Synacthen 试验中口服避孕药的混杂影响。
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Salivary cortisone and cortisol following synacthen, a future replacement for serum cortisol? Commentary to: Use of Salivary Cortisol and cortisone in the high and low dose synacthen test.促肾上腺皮质激素刺激试验后的唾液皮质酮和皮质醇，血清皮质醇的未来替代物？对《高剂量和低剂量促肾上腺皮质激素刺激试验中唾液皮质醇和皮质酮的应用》的评论
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本文引用的文献

1
Investigating the Clinical Appropriateness of Short Synacthen Testing and Utility of Pretest Cortisol to Predict Short Synacthen Testing Outcomes: A Tertiary Center Experience in Southeast Asia.探讨短程促肾上腺皮质激素（Synacthen）试验的临床适宜性及试验前皮质醇水平预测短程促肾上腺皮质激素试验结果的效用：东南亚一家三级中心的经验
Endocr Pract. 2025 Jan;31(1):34-41. doi: 10.1016/j.eprac.2024.10.006. Epub 2024 Oct 18.
2
A New Approach - Home Waking Salivary Cortisone to Screen for Adrenal Insufficiency.一种新方法——家庭唤醒唾液皮质醇以筛查肾上腺功能减退症。
NEJM Evid. 2023 Feb;2(2):EVIDe2200306. doi: 10.1056/EVIDe2200306. Epub 2023 Jan 24.
3
Home Waking Salivary Cortisone to Screen for Adrenal Insufficiency.
家庭唤醒唾液皮质醇筛查肾上腺功能减退症。
NEJM Evid. 2023 Feb;2(2):EVIDoa2200182. doi: 10.1056/EVIDoa2200182. Epub 2023 Jan 6.
4
Salivary Cortisol and Cortisone Can Circumvent Confounding Effects of Oral Contraceptives in the Short Synacthen Test.唾液皮质醇和皮质酮可绕过短期 Synacthen 试验中口服避孕药的混杂影响。
J Clin Endocrinol Metab. 2024 Jun 17;109(7):1899-1906. doi: 10.1210/clinem/dgad763.
5
The association between the cortisol and cortisone awakening responses.皮质醇和可的松觉醒反应之间的关联。
Psychoneuroendocrinology. 2023 Jun;152:106075. doi: 10.1016/j.psyneuen.2023.106075. Epub 2023 Mar 6.
6
What is the value of the 60-minute cortisol measurement in the short synacthen test (SST)? Evidence for the defence.短程促肾上腺皮质激素试验（SST）中60分钟皮质醇测量的价值是什么？辩护理由。
Int J Clin Pract. 2021 Aug;75(8):e14417. doi: 10.1111/ijcp.14417.
7
Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results.重新校准对肾上腺皮质功能评估的思考：“随机”皮质醇与短程促肾上腺皮质激素试验结果的关系。
Cardiovasc Endocrinol Metab. 2021 Apr 12;10(2):137-145. doi: 10.1097/XCE.0000000000000250. eCollection 2021 Jun.
8
Salivary cortisol and cortisone in the clinical setting.临床环境中的唾液皮质醇和可的松。
Curr Opin Endocrinol Diabetes Obes. 2017 Jun;24(3):161-168. doi: 10.1097/MED.0000000000000328.
9
Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone.唾液皮质醇反映了生理条件下和氢化可的松治疗后的皮质醇暴露情况。
J Clin Endocrinol Metab. 2016 Apr;101(4):1469-77. doi: 10.1210/jc.2015-3694. Epub 2016 Jan 26.
10
Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol.吸入糖皮质激素治疗的患者肾上腺抑制非常普遍，可通过早晨皮质醇水平指导管理。
Eur J Endocrinol. 2015 Nov;173(5):633-42. doi: 10.1530/EJE-15-0608. Epub 2015 Aug 20.