Zafirov D H, Palmer J M, Nemeth P R, Wood J D
Eur J Pharmacol. 1985 Sep 10;115(1):103-7. doi: 10.1016/0014-2999(85)90590-4.
Intracellular recording methods were used to study the actions of bombesin, gastrin releasing peptide and vasoactive intestinal peptide on electrical behavior of AH/Type 2 myenteric neurons in guinea-pig ileum in vitro. Each peptide evoked membrane depolarization associated with increased input resistance, enhanced excitability and suppression of hyperpolarizing after-potentials. The effects of the peptides simulated slow synaptic excitation in the myenteric plexus and are consistent with a neurotransmitter or neuromodulatory function.
