Cai Xulong
Department of Pediatrics, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, Yancheng, 224000, People's Republic of China.
J Asthma Allergy. 2025 May 22;18:769-777. doi: 10.2147/JAA.S526788. eCollection 2025.
Patients with asthma frequently experience recurrent symptoms including coughing, wheezing, shortness of breath, and chest tightness. Asthma is a common public health concern. It is characterized by chronic airway inflammation. However, The pathogenesis of asthma is complex. Inflammasomes are signaling platforms that regulate the inflammatory response. There is a correlation between inflammasomes and asthma. Pattern recognition receptors recognize danger signals and participate in inflammasome activation. Nucleotide-binding and oligomerization domain-containing 2 (NOD2), a pattern recognition receptor, senses microbial components and triggers immune responses. There have been studies showing a correlation between NOD2 and asthma. The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) participates in the formation of inflammasomes. NLRP3 are involved in asthma pathogenesis. In this review, we discuss the roles of NOD2 and NLRP3 in the pathogenesis of asthma.
哮喘患者经常出现反复症状，包括咳嗽、喘息、呼吸急促和胸闷。哮喘是一个常见的公共卫生问题。它的特征是慢性气道炎症。然而，哮喘的发病机制很复杂。炎性小体是调节炎症反应的信号平台。炎性小体与哮喘之间存在关联。模式识别受体识别危险信号并参与炎性小体的激活。含核苷酸结合寡聚化结构域2（NOD2）是一种模式识别受体，可感知微生物成分并触发免疫反应。已有研究表明NOD2与哮喘之间存在关联。含pyrin结构域3的核苷酸结合寡聚化结构域样受体（NLRP3）参与炎性小体的形成。NLRP3参与哮喘的发病机制。在这篇综述中，我们讨论了NOD2和NLRP3在哮喘发病机制中的作用。
