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脑瘫患儿低骨密度的评估与管理

Assessment and management of low bone mineral density in children with cerebral palsy.

作者信息

Rhodes Leslie N, Diaz-Thomas Alicia, Woodland Woodi H, Sawyer Jeffrey R, Spence David D, Warner William C

机构信息

University of Tennessee Health Science Center, Memphis, TN, USA.

Le Bonheur Children's Hospital, Memphis, TN, USA.

出版信息

J Pediatr Soc North Am. 2024 Apr 6;7:100060. doi: 10.1016/j.jposna.2024.100060. eCollection 2024 May.

Abstract

UNLABELLED

Cerebral palsy (CP) is an impairment in motor function and coordination due to a nonprogressive brain injury that occurs pre-, peri-, or postnatally until 2 years of age with a prevalence of 1 to 4 per 1,000 live births. Along with impaired motor function, decreased bone mineral density (BMD) in children with CP is of concern for providers. An algorithm has been created to help identify patients at risk for decreased BMD who are seen by providers. Factors included in the algorithm are medication history, fracture history, ketogenic diet, ambulation status, history of endocrinopathy, and pubertal stage.BMD levels are measured using dual-energy x-ray absorptiometry scans. Once a patient is identified as having decreased BMD several treatment options are available. BMD can be increased through stander use, diet, and bisphosphonate treatment. This paper serves as a summary of the current ways in which children with CP are assessed at each visit, as well as how to treat low BMD once it has been identified.

KEY CONCEPTS

(1)Explain the algorithm used to identify patients at risk for decreased BMD.(2)Review how to assess patients with decreased BMD.(3)Summarize treatment recommendations to increase BMD in children with CP.

摘要

未标注

脑性瘫痪(CP)是一种运动功能和协调性受损的病症,起因是在出生前、围产期或出生后直至2岁时发生的非进行性脑损伤,其在活产儿中的患病率为千分之一至千分之四。除了运动功能受损外,CP患儿的骨矿物质密度(BMD)降低也受到医疗服务提供者的关注。现已创建一种算法,以帮助识别医疗服务提供者所诊治的有BMD降低风险的患者。该算法所包含的因素有用药史、骨折史、生酮饮食、行走状态、内分泌病病史和青春期阶段。使用双能X线吸收测定扫描来测量BMD水平。一旦确定患者存在BMD降低的情况,就有几种治疗选择。可以通过使用支架、饮食和双膦酸盐治疗来提高BMD。本文总结了目前在每次就诊时对CP患儿进行评估的方法,以及在确定BMD降低后如何进行治疗。

关键概念

(1)解释用于识别有BMD降低风险患者的算法。(2)回顾如何评估BMD降低的患者。(3)总结提高CP患儿BMD的治疗建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fa/12088348/286fb7dc0a66/gr1.jpg

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