Bonashevskaia T I, Kabakov A Iu, Suslova V M, Radkevich L A
Farmakol Toksikol. 1985 Jul-Aug;48(4):103-5.
On the third day after a single administration of nitrosodimethylamine (30 mg/kg) to white rats histochemistry reveals the greatest injury to the liver parenchyma. This correlates with a reduction in relative strength of intercellular contacts, an increase in relative strength of the membranes, and an elevation of the membrane potential during liver tissue survival in vitro. The latter fact can be explained, at any rate partially, by the lowering of the activity of cytoplasmic ATPase which competes with electrogenic Na+. K+-ATPase for ATP.
给白鼠单次注射亚硝基二甲胺（30毫克/千克）后的第三天，组织化学显示肝实质损伤最为严重。这与细胞间接触相对强度降低、细胞膜相对强度增加以及体外肝组织存活期间膜电位升高相关。后一事实至少可以部分地通过细胞质ATP酶活性降低来解释，该酶与生电的Na⁺，K⁺ -ATP酶竞争ATP。
