Vinitskiĭ I M, Dubrovina N I, Il'iuchenok R Iu
Farmakol Toksikol. 1985 Jul-Aug;48(4):38-41.
It has been found in experimental behavioral interference during training in two conditioned reflexes, rapidly following each other, that intraperitoneal injection of diazepam (2 mg/kg) 30 min before training potentiates the inhibitory effect of the defensive reaction to the drinking one. Electrophysiological analysis of the modulating effect of amygdaloid stimulation on the peripheral signal transmission via the central gray matter has demonstrated that in the majority of the neurons, diazepam produced a longer and pronounced inhibition of the excitatory reactions in response to electrocutaneous stimulation after conditioning stimulation of the amygdaloid. The data obtained allow an assumption that inhibitory processes determined by the activity of the GABAergic amygdalofugal system underlie the interference interrelations.
在两个相继快速进行的条件反射训练过程中的实验行为干扰研究中发现,训练前30分钟腹腔注射地西泮(2毫克/千克)可增强对饮水防御反应的抑制作用。对杏仁核刺激通过中央灰质对外周信号传递的调节作用进行电生理分析表明,在大多数神经元中,杏仁核条件刺激后,地西泮对电皮肤刺激引起的兴奋反应产生了更长时间且更明显的抑制。所获得的数据使我们可以假设,由GABA能杏仁核传出系统的活动所决定的抑制过程是干扰相互关系的基础。