Rakhmankulova I Kh, Garibova T L, Voronin K E, Tilekeeva U M, Voronina T A
Farmakol Toksikol. 1985 Jul-Aug;48(4):42-6.
The spectrum of the pharmacological activity of piracetam administered for a long time was studied in experiments on mice and rats. It was established that administration of piracetam (300-400 mg/kg i. p.) for 10-42 days brought about potentiation of its antiamnestic effect, retardation of the processes of extinction, an increase in the emotional responsiveness, and preservation of the tranquilizing effect with no side effects (sedative or myorelaxant). The characteristic feature of piracetam effect on the extinction is its ability to decelerate this process only after its prolonged administration. It is assumed that under prolonged administration of piracetam there takes place the formation of a new functional system ensuring the memory trace stabilization.
在对小鼠和大鼠进行的实验中，研究了长期服用吡拉西坦的药理活性谱。已确定，腹腔注射吡拉西坦（300 - 400毫克/千克）10 - 42天可增强其抗遗忘作用，延缓消退过程，提高情绪反应性，并保持镇静作用且无副作用（镇静或肌松作用）。吡拉西坦对消退的影响的特征在于，只有在长期给药后它才有能力减缓这一过程。据推测，在长期服用吡拉西坦的情况下，会形成一个新的功能系统，以确保记忆痕迹的稳定。
