Verstakova O L, Gerchikov L N, Gus'kova T A, Liberman S S, Chicherina L A
Farmakol Toksikol. 1985 Jul-Aug;48(4):99-103.
The toxicology of an original Soviet antidepressant inkasan-3-methyl-8-methoxy-3H, 1,2,5,6-tetrahydropyrazino [1,2,3-ab] beta-carboline hydrochloride was studied in different types of experimental animals (mice, rats, rabbits, dogs). It was established that the drug is less toxic than imipramine. The toxic manifestations (seizures, stereotypy) seen in dogs receiving high doses of inkasan for a long time are likely to be linked with a stimulating component that characterizes the drug action on the central nervous system.
对苏联一种原研抗抑郁药因卡三（盐酸3 - 甲基 - 8 - 甲氧基 - 3H，1,2,5,6 - 四氢吡嗪并[1,2,3 - ab]β - 咔啉）在不同类型实验动物（小鼠、大鼠、兔子、狗）身上进行了毒理学研究。已确定该药物的毒性低于丙咪嗪。长期接受高剂量因卡三的狗出现的毒性表现（癫痫发作、刻板行为）可能与该药物对中枢神经系统作用的刺激成分有关。
