Pashinskiĭ V G, Vysokovskiĭ T M, Khlienko Zh N, Aref'eva A K, Ponomareva L F
Farmakol Toksikol. 1978 May-Jun;41(3):345-7.
The antidepressant drug cephedrine experimentally displays a little acute and chronic toxicity, does not influence the development of allergic reaction in guinea pigs, changes but little the ECG and does not possess teratogenic and embryotoxic properties. When used in a subtoxic dose it is capable of causing dystrophic changes in individual neurons in the cortex and subcortical formations of the central nervous system, to delay the growth of fetuses, especially when administered during the second half of gestation.
抗抑郁药头孢菌素在实验中显示出轻微的急性和慢性毒性，不影响豚鼠过敏反应的发展，对心电图影响很小，且不具有致畸和胚胎毒性。当以亚毒性剂量使用时，它能够引起中枢神经系统皮质和皮质下结构中单个神经元的营养不良性变化，延缓胎儿生长，尤其是在妊娠后半期给药时。
