Skórski T
Folia Histochem Cytobiol. 1985;23(1-2):3-10.
The susceptibility of Ehrlich Ascites Carcinoma (EAC) cells to the action of natural cytotoxic cells of DBA/2 and Balb/c mice in vitro was established. Leukaemia L 1210 cells proved insensitive to the in vitro action of natural cytotoxic cells of DBA/2 mice, but not to those of Balb/c ones. BCG, one of the inductors of cytotoxic NK cells, when administered to DBA/2 or Balb/c mice before introduction of EAC cells inhibited the growth of this tumour but did not retard the development of leukaemia L 1210 in DBA/2 mice. The change in the number of peritoneal exsudate cells (PEC) in DBA/2 mice after intraperitoneal injection of BCG was demonstrated to be dependent on the dose and the time elapsed after bacilli introduction. The antitumour action of BCG does not depend on changes in the number of PEC caused by the bacilli. Both large (3.0 mg) and small (0.02 mg) doses of BCG inhibit the development of EAC in Balb/c mice ("sensitive" to BCG), notwithstanding the time of administration of the bacilli. In DBA/2 mice ("resistant" to BCG) development of EAC can be inhibited only by the large dose of BCG since small one is sometimes ineffective.
已确定艾氏腹水癌细胞（EAC）在体外对DBA/2和Balb/c小鼠自然细胞毒性细胞作用的敏感性。白血病L 1210细胞对DBA/2小鼠自然细胞毒性细胞的体外作用不敏感，但对Balb/c小鼠的自然细胞毒性细胞敏感。细胞毒性NK细胞的诱导剂之一卡介苗，在接种EAC细胞之前给予DBA/2或Balb/c小鼠时，可抑制该肿瘤的生长，但不延缓DBA/2小鼠白血病L 1210的发展。腹腔注射卡介苗后，DBA/2小鼠腹腔渗出细胞（PEC）数量的变化被证明取决于剂量和接种杆菌后的时间。卡介苗的抗肿瘤作用不依赖于杆菌引起的PEC数量变化。无论接种杆菌的时间如何，大剂量（3.0毫克）和小剂量（0.02毫克）的卡介苗均可抑制Balb/c小鼠（对卡介苗“敏感”）中EAC的发展。在DBA/2小鼠（对卡介苗“耐药”）中，只有大剂量的卡介苗才能抑制EAC的发展，因为小剂量有时无效。
