Breed Florine F I, Breed Wim P M, Dercksen Marcus W, Ezendam Nicole, Bijlsma Maarten J, van den Hurk Corina J G
Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Godebaldkwartier 419, 3511 DT, Utrecht, The Netherlands.
Catharina Hospital, Eindhoven, The Netherlands.
Support Care Cancer. 2025 May 28;33(6):503. doi: 10.1007/s00520-025-09526-2.
Chemotherapy-induced alopecia (CIA), a very common and distressing side effect of cancer treatment can be effectively prevented by scalp cooling. The aim of this observational study was to estimate the effect of post-infusion cooling time (PICT) on wearing a head cover for taxane- and anthracycline-based chemotherapies.
The Dutch Scalp Cooling Registry (DSCR), which started in January 2006, collected data from 4680 scalp-cooled patients across 68 Dutch hospitals. Questionnaires on patient, chemotherapy and scalp cooling characteristics were completed by patients and nurses. The patient-reported primary outcome included the use of head covering during the final scalp cooling session. Analysis included patients who had received Docetaxel 75 or 100 mg/m (D75 or D100), Paclitaxel 70-90 or 160-180 mg/m (T70-90 or T160-180), Adriamycin 60 mg/m and Cyclophosphamide 600 mg/m (AC), or 5-Fluorouracil 500 mg/m Epirubicin 90 or 100 mg/m and Cyclophosphamide 500 mg/m (FE90C or FE100C).
Shorter post-infusion cooling times (< 85 minutes) seem to be sufficient for maintaining scalp cooling effectiveness in the chemotherapy regimens studied, with no added benefit from extending cooling time beyond this threshold.
For all anthracycline and taxane-based chemotherapy regimens studied, shorter PICTs delivered comparable results to longer PICTs.
化疗所致脱发（CIA）是癌症治疗中一种非常常见且令人苦恼的副作用，头皮冷却可有效预防。本观察性研究的目的是评估输注后冷却时间（PICT）对基于紫杉烷和蒽环类化疗佩戴头套的影响。
荷兰头皮冷却登记处（DSCR）于2006年1月启动，收集了荷兰68家医院4680例接受头皮冷却患者的数据。患者和护士完成了关于患者、化疗和头皮冷却特征的问卷。患者报告的主要结局包括最后一次头皮冷却疗程期间头套的使用情况。分析纳入接受多西他赛75或100mg/m（D75或D100）、紫杉醇70 - 90或160 - 180mg/m（T70 - 90或T160 - 180）、阿霉素60mg/m和环磷酰胺600mg/m（AC），或5 - 氟尿嘧啶500mg/m、表柔比星90或100mg/m和环磷酰胺500mg/m（FE90C或FE100C）治疗的患者。
在本研究的化疗方案中，较短的输注后冷却时间（<85分钟）似乎足以维持头皮冷却效果，将冷却时间延长至该阈值以上并无额外益处。
对于所有研究的基于蒽环类和紫杉烷的化疗方案，较短的PICT与较长的PICT效果相当。
