Liu Chengzhi, Ren Lingyi, Liu Niu, Niu Mengchu, Xiang Yifei, Wu Xianhua, Lin Changhua, Liang Zhengmin, Yu Meiling, He Jiakang
Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, College of Animal Science and Technology, Guangxi University, Nanning, Guangxi 530004, China; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning 530004, China.
Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, College of Animal Science and Technology, Guangxi University, Nanning, Guangxi 530004, China; Guangxi State Farms Yongxin Animal Husbandry Group. Co.Ltd, Nanning, Guangxi 530022, China.
Food Chem. 2025 Sep 30;487:144870. doi: 10.1016/j.foodchem.2025.144870. Epub 2025 May 21.
This study investigates the potential of Mogroside V (MV), a natural saponin commonly used as a sweetener in food and beverages, as a self-assembled carrier to enhance the oral bioavailability of magnolol (MAG). MAG-MV self-assembled nanomicelles (SAM) were successfully synthesized using an ultrasonic dispersion method to encapsulate MAG. The critical micelle concentration of MV was determined to be 2.64 mg/mL. The resulting MAG-MV SAM exhibited a particle size of 175.47 nm and an encapsulation efficiency of 89.39 %. Furthermore, MAG-MV SAM demonstrated excellent biosafety and significantly increased the apparent permeability coefficient across a Caco-2 cell monolayer model. Pharmacokinetic studies showed a 243 % improvement in the bioavailability of MAG compared to its free form, indicating enhanced intestinal absorption and sustained-release properties. These results suggest that MV is a promising carrier for hydrophobic substances, providing a viable strategy for improving the physicochemical properties of MAG in food applications.
本研究考察了罗汉果甜苷V（MV）作为一种自组装载体以提高厚朴酚（MAG）口服生物利用度的潜力，MV是一种常用于食品和饮料中的天然皂苷。采用超声分散法成功合成了用于包封MAG的MAG-MV自组装纳米胶束（SAM）。测定MV的临界胶束浓度为2.64 mg/mL。所得的MAG-MV SAM粒径为175.47 nm，包封率为89.39%。此外，MAG-MV SAM表现出优异的生物安全性，并显著提高了其在Caco-2细胞单层模型中的表观渗透系数。药代动力学研究表明，与游离形式的MAG相比，其生物利用度提高了243%，表明肠道吸收增强且具有缓释特性。这些结果表明，MV是一种很有前景的疏水性物质载体，为改善MAG在食品应用中的理化性质提供了一种可行策略。
